US11324704B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11324704-B2 |
| Application number | US-201716082594-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 6, 2017 |
| Priority date | Mar 7, 2016 |
| Publication date | May 10, 2022 |
| Grant date | May 10, 2022 |
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Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.
Opening claim text (preview).
The invention claimed is: 1. A sustained drug release sheet comprising a non-woven fabric that is formed from nanofibers containing vitamin B12 in the absence of GDF-5 or GDF-5-related proteins for treating nerve injury and a biocompatible polymer, wherein the vitamin B12 is distributed inside the nanofibers, a content of vitamin B12 in the sustained drug release sheet is in a range of 1 to 30% by weight, the biocompatible polymer is at least one biodegradable aliphatic polyester selected from the group consisting of polycaprolactone or a copolymer thereof, polylactic acid or a copolymer thereof, and polyglycolic acid or a copolymer thereof, and the weight of the sheet is in a range of 1 mg/cm 2 to 100 mg/cm 2 . 2. The sustained drug release sheet according to claim 1 , wherein a content of vitamin B12 in the sustained drug release sheet is in a range of 1 to 10% by weight. 3. The sustained drug release sheet according to claim 1 , wherein the weight of the sheet is in a range of 1 mg/cm 2 to 50 mg/cm 2 . 4. The sustained drug release sheet according to claim 1 , wherein the weight of the sheet is in a range of 1 mg/cm 2 to 10 mg/cm 2 . 5. A sustained drug release sheet comprising a non-woven fabric that is formed from nanofibers containing a drug for treating nerve injury and a biocompatible polymer, wherein the drug consists of vitamin B12, the vitamin B12 is distributed inside the nanofibers, the vitamin B12 is a sole effective ingredient for treating the nerve injury, a content of vitamin B12 in the sustained drug release sheet is in a range of 1 to 30% by weight, the biocompatible polymer is at least one biodegradable aliphatic polyester selected from the group consisting of polycaprolactone or a copolymer thereof, polylactic acid or a copolymer thereof, and polyglycolic acid or a copolymer thereof, and the weight of the sheet is in a range of 1 mg/cm 2 to 100 mg/cm 2 . 6. The sustained drug release sheet according to claim 5 , wherein the content of vitamin B12 in the sustained drug release sheet is 1 to 10% by weight. 7. The sustained drug release sheet according to claim 5 , wherein the weight of the sheet is in a range of 1 mg/cm 2 to 50 mg/cm 2 . 8. The sustained drug release sheet according to claim 5 , wherein the weight of the sheet is in a range of 1 mg/cm 2 to 10 mg/cm 2 .
Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12 · CPC title
Drugs for disorders of the nervous system · CPC title
Growth factors; Growth regulators · CPC title
Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} · CPC title
Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title
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