Methods and Related Kits for Treating and Regenerating Tooth Pulp and Periapical Tissues in a Mammal
US-2018161394-A1 · Jun 14, 2018 · US
US11324568B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11324568-B2 |
| Application number | US-202117389478-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 30, 2021 |
| Priority date | Sep 12, 2019 |
| Publication date | May 10, 2022 |
| Grant date | May 10, 2022 |
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The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.
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The invention claimed is: 1. A same day single visit method for capping a damaged tooth, comprising: applying a treatment composition comprising amelogenin and propylene glycol alginate (“PGA”) to a surface of exposed pulp of the damaged tooth; then capping the damaged tooth by applying a permanent dental restorative on top of the treatment composition present on the exposed pulp, wherein the treatment composition comprises 30 mg amelogenin protein powder in mixture with 1 ml of a combination of propylene glycol alginate and a saline matrix. 2. The method of claim 1 , wherein the amelogenin comprises an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 2, 4 or 6 or a sequence that has at least 95% sequence identity to SEQ ID NOS: 2, 4 or 6 or a fragment thereof having at least 30 contiguous amino acid residues. 3. The method of claim 1 , wherein the treatment composition consists essentially of recombinant human amelogenin, the saline and the propylene glycol alginate. 4. The method of claim 1 , wherein the treatment composition further comprises a remineralization agent selected from the group consisting of a material providing calcium ions, a material providing phosphorous ions, and a material providing fluoride ions. 5. The method of claim 1 , wherein the subject is suffering from amelogenesis imperfecta.
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