Gas chromatograph-ion mobility spectrometry combined equipment

Patent metadata

Field	Value
Publication number	US-11320407-B2
Application number	US-201916714799-A
Country	US
Kind code	B2
Filing date	Dec 16, 2019
Priority date	Dec 18, 2018
Publication date	May 3, 2022
Grant date	May 3, 2022

Abstract

The present disclosure discloses a gas chromatograph-ion mobility spectrometry combined equipment, including: a gas chromatograph device for pre-separating a to-be-detected sample to form a pre-separated sample; an ion mobility spectrometry device in fluid communication with an outlet of the gas chromatograph device for detecting the pre-separated sample; and a gas circulating device in fluid communication with a discharged gas interface of the ion mobility spectrometry device for processing a discharged gas from the ion mobility spectrometry device, wherein the gas circulating device is further in gas communication with the gas chromatograph device for conveying a part of the discharged gas to the gas chromatograph device to serve as a carrier gas, which drives the to-be-detected sample to enter the gas chromatograph device. The miniaturization and the portability of the gas chromatograph-ion mobility spectrometry combined equipment are improved.

First claim

The invention claimed is:

1. A gas chromatograph-ion mobility spectrometry combined equipment, comprising:
a gas chromatograph device, configured to pre-separate a to-be-detected sample to form a pre-separated sample;
an ion mobility spectrometry device, in fluid communication with an outlet of the gas chromatograph device for detecting the pre-separated sample;
a gas circulating device in fluid communication with a discharged gas interface of the ion mobility spectrometry device for processing a discharged gas from the ion mobility spectrometry device, wherein the gas circulating device is in gas communication with the gas chromatograph device for conveying a part of the discharged gas to the gas chromatograph device to serve as a carrier gas, which drives the to-be-detected sample to enter the gas chromatograph device; and
a sample exchange device, comprising a supporting structure and a semipermeable membrane, wherein the supporting structure has a hollow chamber, the semipermeable membrane is arranged in the hollow chamber to divide the hollow chamber into a collected sample chamber and a chromatographic sample chamber, a sample flows from the collected sample chamber to the chromatographic sample chamber through the semipermeable membrane to form the to-be-detected sample, and the gas circulating device is communicated with the inlet of the gas chromatograph device by the chromatographic sample chamber.

2. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 1 , wherein the gas circulating device comprises a discharged gas purification device for purifying the discharged gas, and the part of the discharged gas is purified discharged gas from the discharged gas purification device.

3. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 2 , wherein the gas circulating device further comprises at least one of the following:
a first discharged gas driving device, communicating the discharged gas interface and an inlet of the discharged gas purification device for driving the discharged gas from the ion mobility spectrometry device to enter the discharged gas purification device; and
a second discharged gas driving device, being arranged between an outlet of the discharged gas purification device and an inlet of the gas chromatograph device for driving the part of the discharged gas to enter the gas chromatograph device.

4. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 3 , wherein the first discharged gas driving device comprises a diaphragm pump; and/or, the second discharged gas driving device comprises a booster pump.

5. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 2 , wherein the gas circulating device further comprises at least one of the following:
a first buffer device, communicating the discharged gas interface and an inlet of the discharged gas purification device; and
a second buffer device, communicating an outlet of the discharged gas purification device and an inlet of the gas chromatograph device.

6. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 5 , wherein the first buffer device comprises a first buffer film and a first buffer chamber structure with a first opening, and the first buffer film is disposed at the first opening to seal the first opening; and/or, the second buffer device comprises a second buffer film and a second buffer chamber structure with a second opening, and the second buffer film is disposed at the second opening to seal the second opening.

7. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 5 , wherein the gas circulating device further comprises a second buffer device communicating an outlet of the discharged gas purification device and an inlet of the gas chromatograph device, and the second buffer device communicates the outlet of the discharged gas purification device and a migration gas inlet of the ion mobility spectrometry device, so that a part of discharged migration gas purified by the discharged gas purification device enters the ion mobility spectrometry device to serve as a migration gas.

8. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 2 , wherein the gas circulating device further comprises at least one of the following:
a discharged gas flow rate adjusting component, being arranged between an inlet of the discharged gas purification device and a discharged gas interface of the ion mobility spectrometry device for adjusting the discharge gas flow rate of the discharged gas that flows from the ion mobility spectrometry device to the discharged gas purification device; and
a carrier gas flow rate adjusting component, being arranged between an outlet of the discharged gas purification device and an inlet of the gas chromatograph device for adjusting the carrier gas flow rate of the discharged gas that flows from the discharged gas purification device to the gas chromatograph device.

9. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 1 , comprising a sampling device, and the sampling device comprises a sampling driving device and a sampling head, wherein the sampling driving device and the sampling head are communicated with the chromatographic sample chamber, and the sampling driving device drives the sample collected by the sampling head to enter the collected sample chamber by applying an attraction force to the sample.

10. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 1 , wherein the hollow chamber is a fusiform chamber having smaller cross-sectional areas at both ends and a larger cross-sectional area at a middle, the collected sample chamber is provided with a sample inlet for receiving the sample and a sample exhaust gas outlet for discharging a sample exhaust gas, the sample inlet and the sample exhaust gas outlet being respectively arranged at two ends of the fusiform chamber, and the chromatographic sample chamber is provided with a carrier gas inlet for receiving the part of the discharged gas and a sample output port for outputting a mixture of the to-be-detected sample and the carrier gas to the gas chromatograph device, and the carrier gas inlet and the sample output port being respectively arranged at two ends of the fusiform chamber.

11. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 1 , wherein a guide groove is formed on an inner wall of the hollow chamber, and the guide groove is configured to guide gas in at least one of the collected sample chamber or the chromatographic sample chamber to flow.

12. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 1 , wherein the sample exchange device further comprises at least one of the following: a semipermeable membrane heating device, configured to heat the semipermeable membrane; and a semipermeable membrane cooling device, configured to cool the semipermeable membrane to achieve sample enrichment.

13. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 12 , wherein the sample exchange device further comprises a semipermeable membrane heating device, the semipermeable membrane heating device is configured to perform pulse heating on the semipermeable membrane.

14. The gas chromatograph-ion mobility spectrometry combined equipment according to claim 1 , wherein the gas circulating device comprises a communication port in communication with atmosphere and a communication gas purification device

Assignees

• Nuctech Co Ltd
• Univ Tsinghua

Inventors

• Zhang Qingjun
• Li Yuanjing
• Chen Zhiqiang
• Zhu Weiping
• Liu Yaohong
• Ma Qiufeng
• Li Ge
• Cao Biao
• Yan Lili

Classifications

• G01N30/44 Primary

  using recycling of the fraction to be distributed · CPC title

• G01N30/72

  Mass spectrometers {(mass spectrometers per se H01J49/00)} · CPC title

• G01N30/7206 Primary

  interfaced to gas chromatograph (interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04) · CPC title

• G01N30/34

  of fluid composition, e.g. gradient (G01N30/36 takes precedence) · CPC title

• G01N30/02 Primary

  Column chromatography · CPC title