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US-2019344255-A1 · Nov 14, 2019 · US
Process for converting S-enantiomer to its racemic form
US11319277B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11319277-B2 |
| Application number | US-202016749519-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 22, 2020 |
| Priority date | Mar 17, 2016 |
| Publication date | May 3, 2022 |
| Grant date | May 3, 2022 |
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- Title
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- Abstract
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Abstract
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The present invention relates to a novel process for converting the unwanted S enantiomer form to its useful raceme with respect to a 4-aminoindane derivative and to novel intermediates of said process.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound of Formula IV, wherein, R is selected from a C 1 -C 6 alkyl group or a C 6 -C 10 aryl group, these groups being optionally substituted with one or more of C 1 -C 6 alkyl groups and/or halogen atoms. 2. The compound of claim 1 , which is (R)-N-(7-fluoro-1,1,3-trimethyl-3-hydroxy-1H-indan-4-yl)acetamide. 3. The compound of claim 1 prepared by a process starting from Formula (II), which is (S)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-amine, and comprising the steps of: (a) acylating the (S)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-amine to obtain an indaneamide derivative; and (b) oxidizing said indaneamide derivative to obtain 3-hydroxyl indaneamide derivative. 4. The compound of claim 3 which is (R)-N-(7-fluoro-1,1,3-trimethyl-3-hydroxy-1H-indan-4-yl)acetamide.
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Classifications
the other ring being five-membered, e.g. indane · CPC title
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring · CPC title
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring · CPC title
by reactions not involving the formation of carboxamide groups · CPC title
from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines · CPC title
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Frequently asked questions
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- What does patent US11319277B2 cover?
- The present invention relates to a novel process for converting the unwanted S enantiomer form to its useful raceme with respect to a 4-aminoindane derivative and to novel intermediates of said process.
- Who is the assignee on this patent?
- Fmc Corp
- What technology area does this patent fall under?
- Primary CPC classification C07C209/70. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).