Biomedical patches with aligned fibers

Patent metadata

Field	Value
Publication number	US-11311366-B2
Application number	US-201715497691-A
Country	US
Kind code	B2
Filing date	Apr 26, 2017
Priority date	Jun 17, 2010
Publication date	Apr 26, 2022
Grant date	Apr 26, 2022

Abstract

A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.

First claim

What is claimed is:

1. An artificial dura mater comprising at least a hydrophobic and biodegradable electrospun layer, wherein said layer comprises (a) at least one synthetic biomedical polymer and (b) a fibers structure comprising fibers with a diameter of 1-1000 nm, wherein the fibers structure defines a center, an inner area extending from the center to an inner perimeter, and an outer area extending from the inner perimeter to an outer perimeter, wherein the inner area and the outer area at least partially overlap, the fiber structure comprising a first plurality of radially aliened polymeric fibers extending from the center to the inner perimeter, and a second plurality of radially aliened polymeric fibers extending from the inner perimeter to the outer perimeter; wherein a spatial fiber density of the inner area is substantially the same as a spatial fiber density of the outer area.

2. The artificial dura mater according to claim 1 , wherein the polymer is selected from the group consisting of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), poly(lactic acid) (PLA), polyglycolic acid (PGA), PLA-PCL-PGA ternary copolymers, hydroxyethyl-methacrylate hydrogel, poly(ϵ-caprolactone), and combinations thereof.

3. The artificial dura mater according to claim 1 , wherein the polymer is poly(lactic acid).

4. The artificial dura mater according to claim 1 , wherein the artificial dura mater is in the form of a hydrogel.

5. The artificial dura mater according to claim 1 , wherein the nanofibers have a diameter of from about 215 to about 225 nanometers.

6. The artificial dura mater according to claim 1 , wherein the artificial dura mater further comprises a biological agent, a growth factor, a drug or a combination thereof.

7. The artificial dura mater according to claim 6 , wherein the drug is an antibiotic.

8. The artificial dura mater according to claim 1 , wherein the artificial dura mater comprises polylactic acid and poly(ϵ-caprolactone).

9. The artificial dura mater according to claim 1 , wherein the artificial dura mater consists essentially of synthetic materials.

10. The artificial dura mater according to claim 1 , wherein the artificial dura mater comprises polylactic acid and hydroxyethyl-methacrylate hydrogel.

11. The artificial dura mater according to claim 1 , wherein the artificial dura mater comprises three layers and one layer is disposed between the other two.

12. A method of treating a subject having a defective dura mater, the method comprising
selecting the artificial dura mater according to claim 1 , and
applying said artificial dura mater proximate to said defective dura mater in said subject.

13. A method of treating a subject having a defective dura mater, the method comprising
selecting an artificial dura mater that comprises at least one synthetic polymer and a fibers structure comprising fibers with a diameter of 1-1000 nm, wherein the fibers structure defines a center, an inner area extending from the center to an inner perimeter, and an outer area extending from the inner perimeter to an outer perimeter, wherein the inner area and the outer area at least partially overlap, the fiber structure comprising a first plurality of radially aliened polymeric fibers extending from the center to the inner perimeter, and a second plurality of radially aliened polymeric fibers extending from the inner perimeter to the outer perimeter; wherein a spatial fiber density of the inner area is substantially the same as a spatial fiber density of the outer area, and
applying said artificial dura mater proximate to said defective dura mater in said subject.

14. The method according to claim 13 , wherein the polymer is selected from the group consisting of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), poly(lactic acid) (PLA), polyglycolic acid (PGA), PLA-PCL-PGA ternary copolymers, hydroxyethyl-methacrylate hydrogel, poly(ϵ-caprolactone), and combinations thereof.

15. The method according to claim 13 , wherein the polymer is poly(lactic acid).

16. The method according to claim 13 , wherein the artificial dura mater comprises three layers and one layer is disposed between the other two.

17. The method according to claim 13 , wherein the artificial dura mater further comprises a biological agent, a growth factor, a drug or a combination thereof.

18. The method according to claim 13 , wherein the artificial dura mater comprises polylactic acid and hydroxyethyl-methacrylate hydrogel.

19. The method according to claim 13 , wherein the artificial dura mater consists essentially of synthetic materials.

Assignees

• Univ Washington

Inventors

• Macewan Matthew R
• Xie Jingwei
• Ray Zack
• Xia Younan

Classifications

• C12M25/14

  Scaffolds; Matrices (in general C12N5/0068) · CPC title

• B29C48/05

  Filamentary, e.g. strands · CPC title

• A61L15/42

  Use of materials characterised by their function or physical properties (liquid bandages A61L26/00) · CPC title

• D04H3/073

  Hollow cylinder shaped · CPC title

• B29C48/142

  using force fields, e.g. gravity or electrical fields (B29C48/9165 takes precedence) · CPC title