Intelligent and disposable device for selective electrical stimulation of apoptosis

Patent metadata

Field	Value
Publication number	US-11311234-B2
Application number	US-201715808137-A
Country	US
Kind code	B2
Filing date	Nov 9, 2017
Priority date	May 23, 2017
Publication date	Apr 26, 2022
Grant date	Apr 26, 2022

Abstract

A sensing and treatment device includes an array of metal nanorod electrodes formed on a substrate, the array including first electrodes for sensing, and second electrodes for electrical pulsation. A data processing system is configured to monitor a parameter using the first electrodes and to activate the electrical pulsation in the second electrodes in accordance with a reading of the parameter.

First claim

What is claimed is:

1. A method for fabricating a medical device, comprising:
patterning a metal layer on a substrate;
forming nanorods on the metal layer;
connecting first portions of the nanorods to circuitry of an integrated data processing system configured to activate and control the first portions of the nanorods to function as sensor electrodes to measure a condition; and
connecting second portions of the nanorods to the circuitry of the integrated data processing system configured to activate and control the second portions of the nanorods to function as electrical pulsing electrodes by generating an electrical pulsation from energy received from a power source, the circuitry conditioning the energy such that the generated electrical pulsation induces apoptosis in selected cells in accordance with the condition.

2. The method as recited in claim 1 , wherein the first and second portions of nanorods are configured to have dual functionality with respect to sensing and electrical pulsation.

3. The method as recited in claim 1 , wherein the sensing identifies cancer cells and the electrical pulsation kills the cancer cells.

4. The method as recited in claim 3 , wherein the sensing includes pH sensing.

5. The method as recited in claim 1 , further comprising a magnetically sensitive layer formed on the substrate, the method further comprising guiding the medical treatment device to a treatment location using an external magnetic coil.

6. The method as recited in claim 1 , further comprising mounting the medical treatment device on a flexible elongated medical instrument for deployment in vivo.

7. The method as recited in claim 6 , further comprising deploying the medical treatment device laparoscopically in vivo.

8. The method as recited in claim 1 , further comprising treating cancer with the medical treatment device.

Assignees

• IBM

Inventors

• Deligianni Hariklia
• Doris Bruce B
• Holmes Steven J
• Kinser Emily R
• Lin Qinghuang
• Yu Roy R

Classifications

• H10W42/00

  Arrangements for protection of devices (arrangements for thermal protection H10W40/00) · CPC title

• A61B5/4836 Primary

  Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence) · CPC title

• A61B5/14539

  for measuring pH · CPC title

• A61B5/6852

  Catheters · CPC title

• A61B2562/0285

  Nanoscale sensors · CPC title