Beverage Compositions Containing Bacillus coagulans MTCC 5856
US-2018338508-A1 · Nov 29, 2018 · US
Modulation of immune function by Bacillus coagulans
US11298381B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11298381-B2 |
| Application number | US-201916396876-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 29, 2019 |
| Priority date | Apr 30, 2018 |
| Publication date | Apr 12, 2022 |
| Grant date | Apr 12, 2022 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention discloses a composition comprising heat inactivated spores and/or comprising heat inactivated vegetative cells of probiotic bacteria Bacillus coagulans, and a process for preparing the same. The invention also discloses a method of modulating immune function in mammals by activating macrophages, using a composition comprising Bacillus coagulans in the form of live or heat inactivated spore and/or vegetative cells.
First claim
Opening claim text (preview).
We claim: 1. A method of modulating immune function by macrophage polarization in mammals, said method comprising step of bringing into contact mammalian macrophages with an effective concentration of Bacillus coagulans MTCC 5856 in the form of spore or vegetative cells, to bring about the effect of immune modulation by polarizing macrophages to M1 type. 2. The method as in claim 1 , wherein the spores include heat inactivated or dead spores of Bacillus coagulans. 3. The method as in claim 1 , wherein the vegetative cells include heat inactivated or dead or lysed vegetative cells of Bacillus coagulans. 4. The method as in claim 1 , wherein the polarisation of macrophages to M1 type is brought about by inducing the expression of pro-inflammatory genes and cells surface receptors. 5. The method as in claim 1 , wherein the pro-inflammatory genes are selected from the group comprising IL-1β, IL-6, IL-12p40, IL23, TNF-α, TNOS and iNOS. 6. The method as in claim 1 , wherein the cell surface receptors are selected from the group comprising CD80, CD83, CD86, MHC-II, F4/80 and CD16/32. 7. The method as in claim 1 , wherein the mammal is human. 8. The method as in claim 1 , wherein the composition comprising heat inactivated spores and/or vegetative cells of Bacillus coagulans is formulated with pharmaceutically/nutraceutically accepted excipients, adjuvants in the form of powder, infant formulation, suspension, syrup, emulsion, tablets, capsules, eatable or chewable.
Assignees
Inventors
Classifications
Spore forming or isolating processes · CPC title
Immunomodulators · CPC title
Drugs for immunological or allergic disorders · CPC title
- A61K35/742Primary
Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes · CPC title
Bacteria; Culture media therefor · CPC title
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- What does patent US11298381B2 cover?
- The present invention discloses a composition comprising heat inactivated spores and/or comprising heat inactivated vegetative cells of probiotic bacteria Bacillus coagulans, and a process for preparing the same. The invention also discloses a method of modulating immune function in mammals by activating macrophages, using a composition comprising Bacillus coagulans in the form of live or heat …
- Who is the assignee on this patent?
- Majeed Muhammed, Nagabhushanam Kalyanam, Ali Furqan, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification A61K35/742. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 12 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).