System and method for assessing cardiovascular disease and treatment effectiveness from adipose tissue

Patent metadata

Field	Value
Publication number	US-11295865-B2
Application number	US-202117403956-A
Country	US
Kind code	B2
Filing date	Aug 17, 2021
Priority date	Oct 17, 2018
Publication date	Apr 5, 2022
Grant date	Apr 5, 2022

Abstract

Systems and methods are disclosed for assessing cardiovascular disease and treatment effectiveness based on adipose tissue. One method includes identifying a vascular bed of interest in a patient's vasculature; receiving a medical image of the patient's identified vascular bed of interest; identifying adipose tissue in the received medical image; receiving a geometric vascular model comprising a representation of the patient's identified vascular bed of interest; and computing an inflammation index associated with the geometric vascular model, using the identified adipose tissue.

First claim

What is claimed is:

1. A computer-implemented method for assessing cardiovascular disease and treatment effectiveness based on adipose tissue, the method comprising:
receiving medical image data associated with a region of interest of a patient;
identifying adipose tissue represented in the received medical image data;
obtaining a geometric vascular model that represents at least a portion of the region of interest of the patient;
receiving a selection of a vascular location in the region of interest of the patient;
determining a centerline of the selected vascular location;
determining a volume defined by a radius about the determined centerline of the selected vascular location;
estimating a percentage of the determined volume likely containing adipose tissue based on the identified adipose tissue in the received medical image data and the geometric vascular model; and
computing an inflammation index for the selected vascular location based on the estimated percentage of the determined volume likely containing adipose tissue, wherein the percentage of the determined volume likely containing adipose tissue is a weighted percentage whereby a decreasing weight is applied to adipose tissue at increasing distance from the centerline of the selected vascular location.

2. The computer-implemented method of claim 1 , wherein the radius has a length such that the determined volume include an entirety of the region of interest of the patient.

3. The computer-implemented method of claim 1 , wherein the radius has a length associated with a location of a potential treatment.

4. The computer-implemented method of claim 1 , further comprising:
modifying a blood flow computation of a patient-specific blood flow model based on the determined inflammation index and the patient-specific blood flow model associated with anatomy of the geometric vascular model.

5. The computer-implemented method of claim 4 , wherein modifying the blood flow computation includes modifying one or more of an inflow boundary condition, an outflow boundary condition, or a vessel wall boundary condition of the patient-specific blood flow model based on the determined inflammation index.

6. The computer-implemented method of claim 4 , further comprising:
determining at least one blood flow metric of the patient using the modified blood flow computation.

7. The computer-implemented method of claim 1 , further comprising:
modifying a threshold value of at least one blood flow metric for the patient based on the determined inflammation index.

8. A system for assessing cardiovascular disease and treatment effectiveness based on adipose tissue, comprising:
at least one memory storing instructions; and
at least one processor operatively connected to the at least one memory and configured to execute the instructions to perform operations, including:
receiving medical image data associated with a region of interest of a patient;
identifying adipose tissue represented in the received medical image data;
obtaining a geometric vascular model that represents at least a portion of the region of interest of the patient;
receiving a selection of a vascular location in the region of interest of the patient;
determining a centerline of the selected vascular location;
determining a volume defined by a radius about the determined centerline of the selected vascular location;
estimating a percentage of the determined volume likely containing adipose tissue based on the identified adipose tissue in the received medical image data and the geometric vascular model; and
computing an inflammation index for the selected vascular location based on the estimated percentage of the determined volume likely containing adipose tissue, wherein the percentage of the determined volume likely containing adipose tissue is a weighted percentage whereby a decreasing weight is applied to adipose tissue at increasing distance from the centerline of the selected vascular location.

9. The system of claim 8 , wherein the radius has a length such that the determined volume include an entirety of the region of interest of the patient.

10. The system of claim 8 , wherein the radius has a length associated with a location of a potential treatment.

11. The system of claim 8 , wherein the operations further include:
modifying a blood flow computation of a patient-specific blood flow model based on the determined inflammation index and the patient-specific blood flow model associated with anatomy of the geometric vascular model.

12. The system of claim 11 , wherein modifying the blood flow computation includes modifying one or more of an inflow boundary condition, an outflow boundary condition, or a vessel wall boundary condition of the patient-specific blood flow model based on the determined inflammation index.

13. The system of claim 11 , wherein the operations further include:
determining at least one blood flow metric of the patient using the modified blood flow computation.

14. The system of claim 8 , wherein the operations further include:
modifying a threshold value of at least one blood flow metric for the patient based on the determined inflammation index.

15. A non-transitory computer-readable medium comprising instructions executable by a processor to perform operations, including:
receiving medical image data associated with a region of interest of a patient;
identifying adipose tissue represented in the received medical image data;
obtaining a geometric vascular model that represents at least a portion of the region of interest of the patient;
receiving a selection of a vascular location in the region of interest of the patient;
determining a centerline of the selected vascular location;
determining a volume defined by a radius about the determined centerline of the selected vascular location;
estimating a percentage of the determined volume likely containing adipose tissue based on the identified adipose tissue in the received medical image data and the geometric vascular model; and
computing an inflammation index for the selected vascular location based on the estimated percentage of the determined volume likely containing adipose tissue, wherein the percentage of the determined volume likely containing adipose tissue is a weighted percentage whereby a decreasing weight is applied to adipose tissue at increasing distance from the centerline of the selected vascular location.

16. The non-transitory computer-readable medium of claim 15 , wherein either:
the radius has a length such that the determined volume include an entirety of the region of interest of the patient; or
the radius has a length associated with a location of a potential treatment.

17. The non-transitory computer-readable medium of claim 15 , wherein the operations further include:
modifying a blood flow computation of a patient-specific blood flow model based on the determined inflammation index and the patient-specific blood flow model associated with anatomy of the geometric vascular model, wherein modifying the blood flow computation includes modifying one or more of an inflow boundary condition, an outflow boundary condition, or a vessel wall boundary condition of the patient-specific blood flow model based on the determined inflammation index;
determining at least one blood flow metric of the patient using the modified blood flow computation; and
modifying a threshold value of at least one blood flow metric for the patient based on the determined inflammation index.

Assignees

• Heartflow Inc

Inventors

• Rabbat Mark
• Taylor Charles
• Schaap Michiel
• Fonte Timothy
• Grady Leo

Classifications

• G16H30/20

  for handling medical images, e.g. DICOM, HL7 or PACS · CPC title

• A61B5/4848

  Monitoring or testing the effects of treatment, e.g. of medication · CPC title

• A61B5/02007

  Evaluating blood vessel condition, e.g. elasticity, compliance · CPC title

• G16H50/30 Primary

  for calculating health indices; for individual health risk assessment · CPC title

• A61B6/504

  for diagnosis of blood vessels, e.g. by angiography · CPC title