Automatic analysis device

Patent metadata

Field	Value
Publication number	US-11293935-B2
Application number	US-201716081259-A
Country	US
Kind code	B2
Filing date	Jan 12, 2017
Priority date	Mar 4, 2016
Publication date	Apr 5, 2022
Grant date	Apr 5, 2022

Abstract

An automatic analysis device includes a reagent container, a reagent disk for holding the reagent container, a dispensing mechanism for dispensing a solution into the reagent container, an inversion mixing mechanism for subjecting the reagent container to inversion mixing, and a control unit for controlling the dispensing mechanism and the inversion mixing mechanism. The inversion mixing mechanism has a rotating mechanism for rotating the reagent container and a tilting mechanism for tilting a rotating shaft of the reagent container. The reagent container has a lid which can be pierced. The lid has a tubular mechanism having an opening part formed at the tip end and extending inside the reagent container. The control unit controls the dispensing conditions of the dispensing mechanism.

First claim

The invention claimed is:

1. An automatic analysis device comprising
a reagent container,
a reagent disk for holding the reagent container,
a dispensing mechanism for dispensing a liquid into the reagent container,
an inversion mixing mechanism for subjecting the reagent container to inversion mixing, and
a control unit for controlling the dispensing mechanism and the inversion mixing mechanism, wherein
the inversion nixing mechanism comprises:
a rotating mechanism comprising a first motor for rotating the reagent container via a rotating shaft coupled directly to the first motor, and
a tilting mechanism comprising a second motor, which is coupled to a pulley disposed on the rotating mechanism, for tilting both the first motor and rotating shaft of the rotating mechanism,
wherein a rotational axis of the pulley is disposed perpendicularly to the rotational axis of the rotating shaft of the rotating mechanism,

the reagent container comprises:
a lid that can be pierced by a nozzle of the dispensing mechanism or a piercing needle to form an opening, the lid having a tubular mechanism that has the opening formed at a tip end and extends inside the reagent container to a depth corresponding to the center of gravity of the reagent container when empty, and

the control unit is configured to:
control dispensing conditions of the dispensing mechanism so that the position of the opening formed at the tip end of the tubular mechanism is above the liquid surface of the liquid contained in the reagent container regardless of whether the reagent container is held upright, upside-down, or sideways by the inversion mixing mechanism,
control placing the reagent container on the reagent disk,
control piercing of the lid by the dispensing mechanism to form the opening,
control dispensing the liquid into the reagent container, and
control performing inversion mixing by tilting the reagent container placed in the inversion mixing mechanism while rotating the reagent container.

2. The automatic analysis device according to claim 1 , wherein
the reagent container contains a freeze-dried reagent in advance,
the liquid dispensed by the dispensing mechanism is a solvent for dissolving the freeze-dried reagent,
the control unit controls the rotating mechanism and the tilting mechanism so as to rotate the reagent container while holding the rotating shaft of the rotating mechanism sideways or upside-down when the freeze-dried reagent is dissolved in the solvent.

3. The automatic analysis device according to claim 2 , wherein
the control unit controls the rotating mechanism and the tilting mechanism so as to rotate the reagent container while tilting the rotating shaft of the rotating mechanism in the range of about 350 to 550 when a mixed liquid obtained after dissolving the freeze-dried reagent in the solvent is mixed.

4. The automatic analysis device according to claim 3 , wherein
the control unit controls the rotating mechanism and the tilting mechanism so as to rotate the reagent container while tilting the rotating shaft of the rotating mechanism at about 450.

5. The automatic analysis device according to claim 1 , wherein
the liquid dispensed by the dispensing mechanism is a reagent having a concentration gradient,
the control unit controls the rotating mechanism and the tilting mechanism so as to rotate the reagent container while tilting the rotating shaft of the rotating mechanism in the range of about 350 to 550 when the reagent is mixed.

6. The automatic analysis device according to claim 5 , wherein
the control unit controls the rotating mechanism and the tilting mechanism so as to rotate the reagent container while tilting the rotating shaft of the rotating mechanism at about 45°.

7. The automatic analysis device according to claim 1 , wherein
the control unit controls the dispensing mechanism so as to dispense the liquid in several divided portions into the reagent container.

8. The automatic analysis device according to claim 1 , wherein
the rotational axis of the pulley intersects the rotational axis of the rotating shaft of the rotating mechanism.

9. The automatic analysis device according to claim 1 , further comprising: a belt disposed on the pulley and mechanically coupled to the second motor.

10. An analysis method using an automatic analysis device comprising:
a reagent container,
a reagent disk for holding the reagent container,
a dispensing mechanism for dispensing a solution into the reagent container,
an inversion mixing mechanism for subjecting the reagent container to inversion mixing, and
a control unit for controlling the dispensing mechanism and the inversion mixing mechanism,
the inversion mixing mechanism comprising:
a rotating mechanism comprising a first motor for rotating the reagent container via a rotating shaft coupled directly to the first motor, and
a tilting mechanism comprising a second motor, which is coupled to a pulley disposed on the rotating mechanism, for tilting both the first motor and the rotating shaft of the rotating mechanism,
wherein a rotational axis of the pulley is disposed perpendicularly to the rotational axis of the rotating shaft of the rotating mechanism,

the reagent container comprising:
a lid that can be pierced by a nozzle of the dispensing mechanism or a piercing needle to form an opening, the lid having a tubular mechanism that has the opening formed at a tip end and extends inside the reagent container to a depth corresponding to the center of gravity of the reagent container when empty,

the control unit:
controlling dispensing conditions of the dispensing mechanism so that the position of the opening formed at the tip end of the tubular mechanism is above the liquid surface of the solution contained in the reagent container regardless of whether the reagent container is held upright, upside-down, or sideways by the inversion mixing mechanism,
placing the reagent container on the reagent disk, piercing the lid by the dispensing mechanism to form the opening, dispensing the solution into the reagent container, and
performing inversion mixing by tilting the reagent container placed in the inversion mixing mechanism while rotating the reagent container.

11. The analysis method according to claim 10 , wherein the rotational axis of the pulley intersects the rotational axis of the rotating shaft of the rotating mechanism.

12. The analysis method according to claim 10 , wherein: a belt is disposed on the pulley and mechanically coupled to the second motor.

Assignees

• Hitachi High Tech Corp

Inventors

• Konishi Rei
• Makino Akihisa

Classifications

• G01N35/1079 Primary

  with means for piercing stoppers or septums · CPC title

• B01L2300/044

  pierceable, e.g. films, membranes · CPC title

• B01L3/523

  with means for closing or opening · CPC title

• G01N2035/0443

  for reagents · CPC title

• B01L3/00

  Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers · CPC title