Systems and methods for preventing, diagnosing, and/or treating one or more medical conditions via neuromodulation

Patent metadata

Field	Value
Publication number	US-11291847-B2
Application number	US-201715851842-A
Country	US
Kind code	B2
Filing date	Dec 22, 2017
Priority date	Jun 16, 2015
Publication date	Apr 5, 2022
Grant date	Apr 5, 2022

Abstract

Described are systems and methods for preventing, diagnosing, and/or treating one or more medical conditions. The medical conditions can be ocular and/or neurological diseases, disorders, and/or conditions. The systems and methods can employ a microstimulator that is configured to be placed within an anatomical structure of a subject. The microstimulator can be capacitively linked to an external electronic device to provide neuromodulation to a biological target site proximal to the anatomical structure. The microstimulator can include a body and an electrically conductive insert arranged within the body to create a capacitively coupled link with the external electronic device. The electrically conductive insert can receive a power signal from an external electronic device and convert the power signal to deliver a therapy signal to the biological target site.

First claim

What is claimed is:

1. A method for treating, diagnosing, or preventing a medical condition in a subject comprising:
establishing a capacitive link between a microstimulator, positioned in an anatomical structure of the subject innervated by one or more nerves, the microstimulator comprising an internal conductive plate, and an external electronic device, comprising an external conductive plate, wherein the capacitive link comprises at least the external conductive plate and the internal conductive plate being aligned across a dielectric medium:
wherein the microstimulator further comprises a body and an electrically conductive insert arranged within the body comprising the internal conductive plate and a power electrode, electrically connected to the internal conductive plate, and in physical contact a first portion of the anatomical structure, and a return electrode in physical contact with a second portion of the anatomical structure;
wherein the power electrode and the return electrode are electrically isolated from each other within the microstimulator; and

using the external electronic device to deliver a power signal to the internal conductive plate in the micrsotimulator through the capacitive link;
wherein delivering the power signal to the microstimulator creates an electrical potential difference between the power electrode and the return electrode, and thereby generates a therapy signal comprising an electrical field that is delivered directly to a target portion of the anatomical structure.

2. The method of claim 1 , wherein the body comprises a horizontal portion, a vertical portion, and a curved portion extending between and connecting the horizontal portion and the vertical portion,
wherein the horizontal portion and the vertical portion are arranged at an angle relative to one another, and
wherein the horizontal portion is longer than the vertical portion.

3. The method of claim 1 , wherein the therapy signal is configured to treat and/or diagnose a neurological disease.

4. The method of claim 3 , wherein the neurological disease is at least one of dry eye, Meibomian gland dysfunction, goblet cell degranulation, presbyopia, Sjogren's syndrome, pain, ocular pain, corneal pain, facial pain, atypical facial pain, neuralgia, facial neuralgia, trigeminal neuralgia, ocular neuralgia, autonomic dysfunctions, headache, primary headache, secondary headache, myasthenia gravis, intravitreal injection side effects, contact lens intolerance, contact lens over wear, contact lens keratopathy or glaucoma.

5. The method of claim 1 , wherein the therapy signal is configured to treat and/or diagnose an ocular disorder.

6. The method of claim 5 , wherein the ocular disorder is ocular hypertension.

7. The method of claim 1 , wherein the therapy signal is configured to induce a neurological reflex to provide a therapeutic effect.

8. The method of claim 7 , wherein the therapeutic effect is at least one of upregulation or downregulation of one or more cellular pathways to treat a neurological disease.

9. The method of claim 1 , wherein the therapy signal is configured to tighten skin, reduce skin redness, treat lid ptosis, or reduce wrinkles.

10. The method of claim 1 , wherein the therapy signal is delivered at least one of prior to a surgical procedure, during the surgical procedure, and after a surgical procedure.

11. The method of claim 1 , wherein the electrical field is generated from current flow through a portion of the subject between the power electrode and the return electrode.

12. The method of claim 11 , wherein the current is generated in response to changing impedance of the capacitive link.

13. The method of claim 1 , wherein the anatomical structure of the subject innervated by one or more nerves comprises a nasolacrimal drainage system of the subject.

14. The method of claim 1 , wherein the internal conductive plate is curved.

15. The method of claim 1 , wherein the external conductive plate and the internal conductive plate are aligned in a generally parallel configuration across the dielectric medium.

16. The method of claim 1 , wherein establishing the capacitive link comprises varying a voltage at the external conductive plate.

Assignees

• Univ Colorado Regents

Inventors

• Caparso Anthony V
• Kahook Malik
• Mandava Naresh
• Lemire Noah
• Farwick Adam
• Wilder Steve
• Risser Steve

Classifications

• A61N1/0551

  Spinal or peripheral nerve electrodes · CPC title

• A61N1/3787 Primary

  from an external energy source · CPC title

• A61B3/16

  for measuring intraocular pressure, e.g. tonometers · CPC title

• A61N1/37211

  Means for communicating with stimulators · CPC title

• A61N1/36057

  adapted for stimulating afferent nerves · CPC title