Multiple dosage injector with rotating screw dosage system

Patent metadata

Field	Value
Publication number	US-11291773-B2
Application number	US-201916389627-A
Country	US
Kind code	B2
Filing date	Apr 19, 2019
Priority date	Mar 13, 2013
Publication date	Apr 5, 2022
Grant date	Apr 5, 2022

Abstract

A dispensing mechanism for delivering a dosage of medicament including a housing having a proximal-distal axis; a plunger rod having a screw thread and configured to advance along the proximal-distal axis relative to the housing; a user-operable push button moveable along the proximal-distal axis relative to the housing; a twist driver threadably engaged with the push button such that movement of the push button towards the distal end of the housing causes rotation of the twist driver about the proximal-distal axis; and a driver engaged with the twist driver such that rotation of the twist driver causes rotation of the driver, the driver also engaged with a portion of the plunger rod such that rotation of the driver causes rotation of the plunger rod, advancing the plunger rod along the proximal-distal axis relative to the housing.

First claim

The invention claimed is:

1. An injector comprising:
a housing having a proximal-distal axis, the housing configured to receive a medicament cartridge;
a plunger rod having a screw thread and configured to advance along the proximal-distal axis relative to the housing to dispense medicament from the medicament cartridge;
an activation mechanism moveable along the proximal-distal axis relative to the housing;
a twist driver threadably engaged with the activation mechanism such that movement of the activation mechanism towards a distal end of the housing causes rotation of the twist driver about the proximal-distal axis;
a flexible column coupled to the activation mechanism, the flexible column configured to engage the housing to limit movement of the activation mechanism to one direction along the proximal-distal axis; and
a driver engaged with the twist driver such that rotation of the twist driver causes rotation of the driver, the driver also engaged with a portion of the plunger rod such that rotation of the driver causes rotation of the plunger rod, advancing the plunger rod along the proximal-distal axis relative to the housing.

2. The injector of claim 1 , wherein the medicament includes a parathyroid hormone.

3. The injector of claim 2 , wherein the parathyroid hormone is triparatide.

4. The injector of claim 1 , further comprising:
an anti-reverse mechanism including:
at least one ratchet integrally formed on an internal surface of the housing; and
the flexible column, wherein the flexible column includes a flexible column protrusion at a proximal end thereof,

wherein as the activation mechanism moves along the proximal-distal axis, the flexible column protrusion engages the at least one ratchet and restricts movement of the activation mechanism to one direction during a firing motion and a resetting motion.

5. The injector of claim 4 , wherein the flexible column protrusion is generally elliptically shaped.

6. The injector of claim 4 , wherein the activation mechanism includes a protrusion configured to engage the housing such that the activation mechanism is prevented from moving along the proximal-distal axis after an injection.

7. The injector of claim 1 , wherein the activation mechanism includes a sidewall with an opening in the sidewall.

8. The injector of claim 7 , wherein at least a portion of the flexible column is positioned within the opening.

9. The injector of claim 1 , further comprising:
a nut fixated within the housing having protrusions on an internal surface that engage the screw thread of the plunger rod such that as the plunger rod rotates, the plunger rod is advanced along the proximal-distal axis relative to the housing.

10. The injector of claim 1 , wherein the twist driver further includes a ratchet flap that is configured to engage a lip of the driver such that the twist driver can axially rotate about the proximal-distal axis in generally only one direction.

11. The injector of claim 1 , further comprising a biasing member disposed within the activation mechanism to facilitate movement of the activation mechanism from a fired position to a reset position.

12. The injector of claim 1 , wherein the housing includes a cartridge sleeve releasably coupled to housing, the cartridge sleeve configured to hold the medicament cartridge.

13. The injector of claim 12 , further comprising
a needle assembly releasably coupled to the cartridge sleeve, the needle assembly in fluid communication with the medicament cartridge.

14. The injector of claim 1 , wherein the plunger rod includes a first thread having a first thread pitch and a second thread having a second thread pitch, the first thread pitch being different from the second thread pitch.

15. The injector of claim 14 , wherein the first thread pitch is configured such that the injector self-primes upon initial movement of the activation mechanism.

16. The injector of claim 1 , wherein the activation mechanism comprises a user-operable push button.

17. The injector of claim 1 , wherein the activation mechanism includes a protrusion configured to engage the housing such that the activation mechanism is prevented from moving along the proximal-distal axis.

Assignees

• Antares Pharma Inc

Inventors

• Newton Benjamin
• Madsen Patrick
• Rust Matthew
• Cox Janice

Classifications

• A61M5/31536 Primary

  Blocking means to immobilize a selected dose, e.g. to administer equal doses · CPC title

• A61M2005/202

  cocking means, e.g. to bias the main drive spring of an injector · CPC title

• A61M5/31585

  performed by axially moving actuator, e.g. an injection button · CPC title

• G01F11/023

  with provision for varying the stroke of the piston · CPC title

• A61M5/31551

  including axial movement of dose setting member · CPC title