Soluble metallogels including antimicrobial silver metallogels

Patent metadata

Field	Value
Publication number	US-11291203-B2
Application number	US-201916706553-A
Country	US
Kind code	B2
Filing date	Dec 6, 2019
Priority date	Aug 20, 2019
Publication date	Apr 5, 2022
Grant date	Apr 5, 2022

Abstract

A product includes a metallogel material having metal ions dispersed in an assembly having an organic compound. A method includes combining a metal salt, an organic compound precursor, and a glyme for forming a metallogel material having metal ions dispersed in an assembly having an organic compound.

First claim

What is claimed is:

1. A method, comprising:
contacting a metallogel material with an object for disinfecting the object and providing adhesion thereto, wherein the metallogel material comprises a coinage metal-thiolate metallopolymer and dispersed silver metal ions having antimicrobial properties, wherein the metallogel material is represented as Formula I:

2. The method of claim 1 , wherein the contacting includes spraying the metallogel material onto the object.

3. The method of claim 1 , comprising altering a viscosity of the metallogel material by adding a solvent thereto prior to the contacting.

4. The method of claim 1 , wherein the metallogel material is powdered and packaged in a package, and comprising adding a solvent to the powdered metallogel material for forming an antimicrobial topical treatment, wherein the contacting includes applying the antimicrobial topical treatment to a wound.

5. The method of claim 4 , wherein the package is a bandage.

6. The method of claim 1 wherein the dispersed silver metal ions form an ionic bridge between a pair of the coinage metal-thiolate moieties of the metallopolymer.

7. An antimicrobial product, comprising:
a metallogel material comprising a coinage metal-thiolate metallopolymer and dispersed silver metal ions having antimicrobial properties, wherein the metallogel material is represented as Formula I:

8. The antimicrobial product of claim 7 , comprising a solvent combined with the metallogel material to form an antimicrobial mixture and the antimicrobial mixture is in the form of a spray, paste, or topical gel.

9. The antimicrobial product of claim 7 , wherein the dispersed silver metal ions form an ionic bridge between a pair of the coinage metal-thiolate moieties of the metallopolymer.

10. The antimicrobial product of claim 7 , wherein the metallogel material has a silver-cysteine structure that is effective to disguise the silver metal ions from bacteria metal-limitation processes.

11. The antimicrobial product of claim 7 , wherein the silver metal ions are present in the metallogel material in a concentration of at least 25 μg/mL.

12. A medical product, comprising:
a bandage having coupled thereto the metallogel material according to claim 7 .

13. The medical product of claim 12 , wherein the metallogel material is coupled to the bandage in a powdered and/or solid form.

14. The medical product of claim 12 , wherein the metallogel material coupled to the bandage is configured to function as an adhesive for the bandage.

15. The medical product of claim 14 , wherein the metallogel material coupled to the bandage is configured to function as the adhesive for the bandage upon contact of the metallogel material with a solvent and/or a bodily fluid.

16. The medical product of claim 12 , wherein the bandage comprises a drug releasing scaffold.

17. The medical product of claim 13 further comprising instructions for adding a solvent to the powdered and/or solid metallogel material to form an antimicrobial topical treatment.

Assignees

• L Livermore Nat Security Llc
• Univ Colorado State Res Found

Inventors

• Compel William
• Morrison Keith
• Armstrong James
• Ackerson Christopher J

Classifications

• A61L15/44

  Medicaments · CPC title

• A61L15/20

  containing organic materials · CPC title

• A61L2300/104

  Silver, e.g. silver sulfadiazine · CPC title

• A61L2300/404

  Biocides, antimicrobial agents, antiseptic agents · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title