Implantable device

Patent metadata

Field	Value
Publication number	US-11285305-B2
Application number	US-201716467354-A
Country	US
Kind code	B2
Filing date	Dec 7, 2017
Priority date	Dec 7, 2016
Publication date	Mar 29, 2022
Grant date	Mar 29, 2022

Abstract

The invention relates to an implantable device suitable for being fixed in a fixation position to a wall of a patient's stomach, the implantable device being accommodated in the stomach when the implantable device is in the fixation position, the implantable device being characterised in that it comprises a reserve of an active substance and an injector suitable for administering the active substance to the patient.

First claim

The invention claimed is:

1. An implantable device suitable for being fixed in a fixation position to a wall of the stomach of a patient, the implantable device being accommodated in the stomach when the implantable device is in the fixation position,
the implantable device comprising a reserve of an active substance and an injector suitable for administering the active substance to the patient,
wherein
the injector is configured to inject the active substance into a bodily fluid of the patient,
the injector includes two catheters, the injector being configured to administer the active substance to the patient via at least one of the two catheters,
the injector is configured to aspirate, via one of the two catheters, the bodily fluid of the patient and to discharge, via the other catheter of the two catheters, the aspirated bodily fluid, and
the active substance is chosen from a set formed of: insulin, levodopa, an analgesic and an anticancer drug.

2. The implantable device according to claim 1 , wherein the bodily fluid is peritoneal fluid or blood.

3. The implantable device according to claim 1 , wherein the implantable device comprises a sensor and at least one of the two catheters suitable for directing the bodily fluid of the patient to the sensor, the sensor being suitable for measuring at least one value of a level of a biological marker in the bodily fluid.

4. The implantable device according to claim 3 , further comprising a controller suitable for commanding the administration, by the injector, of the active substance according to the at least one measured value of the level of the biological marker.

5. The implantable device according to claim 4 , wherein the controller is suitable for computing a frequency and/or a dose of active substance to be administered to the patient according to the at least one measured value of the level of the biological marker.

6. The implantable device according to claim 3 , wherein the bodily fluid is peritoneal fluid or blood.

7. The implantable device according to claim 1 , wherein the implantable device comprises an electrical power supply including a removable electrical energy reserve and a connector suitable for accommodating the electrical energy reserve, the electrical energy reserve being suitable for electrically powering the injector when the electrical energy reserve is connected electrically to the connector in a connection position.

8. The implantable device according to claim 1 , wherein the implantable device comprises an electrical power supply suitable for generating an electrical power supply current of the injector by reacting at least one chemical species present in the body of the patient.

9. The implantable device according to claim 1 , wherein the implantable device comprises an electrical power supply suitable for generating an electrical power supply current of the injector by converting mechanical energy into electrical energy.

10. The implantable device according to claim 1 , wherein the injector is configured to inject the active substance into the discharged bodily fluid.

11. The implantable device according to claim 1 , wherein at least one of the two catheters is made of a porous material.

12. The implantable device according to claim 11 , wherein the porous material is suitable for being traversed by the active substance and/or by the bodily fluid of the patient.

13. A method for administering an active substance to a patient utilizing an implantable device suitable for being fixed in a fixation position to a wall of the stomach of the patient, the implantable device being accommodated in the stomach when the implantable device is in the fixation position, the implantable device including a reserve of the active substance and an injector suitable for administering the active substance to the patient,
wherein,
the injector is configured to inject the active substance into a bodily fluid of the patient,
the injector includes two catheters, the injector being configured to administer the active substance to the patient via at least one of the two catheters, and
the two catheters include a first catheter and a second catheter, a free end of the first catheter being placed in an organ or a cavity from which a bodily fluid is to be aspirated, and a free end of the second catheter being placed in an organ or a cavity wherein the active substance is to be injected,

the method comprising:
creating a flow of bodily fluid transiting via the first and second catheters, from an intake end to a discharge end, enabling the injection of the active substance in the flow of bodily fluid,
wherein the injector aspirates, via one of the two catheters, the bodily fluid of the patient and discharges, via the other catheter of the two catheters, the aspirated bodily fluid, and
the active substance is chosen from a set formed of: insulin, levodopa, an analgesic and an anticancer drug.

14. The method according to claim 13 , further comprising:
positioning the implantable device against the wall of the stomach, wherein the second catheter traverses the wall of the stomach, and
injecting the active substance via the second catheter.

15. The method according to claim 13 , wherein,
the implantable device further comprises a sensor and at least one catheter of the first and second catheters suitable for directing the bodily fluid of the patient to the sensor, the sensor being suitable for measuring at least one value of a level of a biological marker in the bodily fluid, and
the method further comprises measuring the level of the biological marker and commanding administration of the active substance.

16. The method according to claim 15 , wherein, the implantable device further comprises a controller suitable for commanding the administration, by the injector, of the active substance according to the at least one measured value of the level of the biological marker, the method further comprises controlling an active substance injection flow rate, over a determined, controlled or monitored period of time.

17. The method according to claim 16 , wherein,
the implantable device further comprises an electrical power supply including a removable electrical energy reserve and a connector suitable for accommodating the electrical energy reserve, the electrical energy reserve being suitable for electrically powering the injector when the electrical energy reserve is connected electrically to the connector in a connection position, and
the method further comprises detecting a remaining level of electrical energy of the implantable device and triggering a change of energy reserve.

Assignees

• Univ Grenoble Alpes
• Centre Hospitalier Univ Grenoble Alpes

Inventors

• Cinquin Philippe
• Tuvignon Patrick

Classifications

• A61M2210/1017

  Peritoneal cavity · CPC title

• A61M2205/825

  using mechanical generation of electricity, e.g. hand cranked generators · CPC title

• A61M2230/201

  Glucose concentration · CPC title

• A61B5/14503

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors (A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence) · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title