Particles

Patent metadata

Field	Value
Publication number	US-11285240-B2
Application number	US-202017010708-A
Country	US
Kind code	B2
Filing date	Sep 2, 2020
Priority date	Mar 26, 2015
Publication date	Mar 29, 2022
Grant date	Mar 29, 2022

Abstract

Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.

First claim

We claim:

1. An embolic system including:
a composition including embolic particles having an organic polymer backbone including a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof; and
at least one monomer,
wherein the embolic particles are configured to be larger than an opening of a mesh of a medical device.

2. The embolic system of claim 1 , wherein the opening is less than about 0.09 inches.

3. The embolic system of claim 1 , wherein the opening is less than about 0.08 inches.

4. The embolic system of claim 1 , wherein the opening is less than about 0.07 inches.

5. The embolic system of claim 1 , wherein the opening is less than about 0.06 inches.

6. The embolic system of claim 1 , wherein the opening is less than about 0.05 inches.

7. The embolic system of claim 1 , wherein the opening is less than about 0.04 inches.

8. The embolic system of claim 1 , wherein the medical device is a flow diverting stent.

9. The embolic composition of claim 1 , wherein the composition includes a visualization agent.

10. The embolic composition of claim 9 , wherein the visualization agent is particles of radiopaque materials or halogen containing monomers.

11. The embolic composition of claim 10 , wherein the halogen containing monomer is an iodine containing monomer.

12. The embolic composition of claim 11 , wherein the iodine containing monomer has a structure:

13. The embolic composition of claim 10 , wherein the particles of radiopaque materials include barium, bismuth, tantalum, platinum, and gold.

14. The embolic composition of claim 10 , wherein the particles of radiopaque materials include barium sulfate.

15. The embolic composition of claim 10 , wherein the particles of radiopaque materials include bismuth.

16. The embolic composition of claim 1 , wherein the at least one monomer includes ionic groups.

17. The embolic composition of claim 16 , wherein the monomer containing ionic groups is sodium acrylate.

18. The embolic composition of claim 1 , wherein the prepolymer solution further includes a crosslinker.

19. The embolic composition of claim 18 , wherein the crosslinker has a structure:

wherein each n is independently 1-20;

wherein d, e, and f are each independently 1-20; or

20. The embolic composition of claim 1 , wherein the macromer is a crosslinker.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Plotkin Steve
• Wu Xinping

Classifications

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title

• A61L24/001

  Use of materials characterised by their function or physical properties · CPC title

• A61L24/06 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} · CPC title

• C08F222/385

  Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide · CPC title

• C08L33/10

  Homopolymers or copolymers of methacrylic acid esters · CPC title