Regulating alkaloids
US-2016032298-A1 · Feb 4, 2016 · US
Enzyme and application thereof
US11279916B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11279916-B2 |
| Application number | US-201716090535-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 31, 2017 |
| Priority date | Apr 1, 2016 |
| Publication date | Mar 22, 2022 |
| Grant date | Mar 22, 2022 |
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- Title
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Abstract
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Provides an artificial enzyme obtained by improving upon a sequence of a natural nicotine dehydrogenase, wherein the improvement comprises replacing at least one amino acid hindering product release with an amino acid with smaller side chains, thereby improving a catalytic rate.
First claim
Opening claim text (preview).
The invention claimed is: 1. An enzyme, the enzyme having the activity for catalyzing the conversion reaction from compound I to compound II as shown by the following formula: wherein the enzyme has an amino acid sequence as shown in SEQ ID NO:2, or as shown in SEQ ID NO:8, or as shown in SEQ ID NO:9, or as shown in SEQ ID NO:10, or as shown in SEQ ID NO:11.
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Classifications
Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title
- C12N9/0012Primary
acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) · CPC title
Oxidoreductases (1) · CPC title
Nicotine dehydrogenase (1.5.99.4) · CPC title
Monoamine oxidase (1.4.3.4) · CPC title
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- What does patent US11279916B2 cover?
- Provides an artificial enzyme obtained by improving upon a sequence of a natural nicotine dehydrogenase, wherein the improvement comprises replacing at least one amino acid hindering product release with an amino acid with smaller side chains, thereby improving a catalytic rate.
- Who is the assignee on this patent?
- Univ Shanghai Jiaotong
- What technology area does this patent fall under?
- Primary CPC classification C12N9/0012. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).