Processes for preparing ACC inhibitors and solid forms thereof
US-10745412-B2 · Aug 18, 2020 · US
Processes for preparing ACC inhibitors and solid forms thereof
US11279710B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11279710-B2 |
| Application number | US-202016924924-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 9, 2020 |
| Priority date | Mar 3, 2017 |
| Publication date | Mar 22, 2022 |
| Grant date | Mar 22, 2022 |
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- Title
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Abstract
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The present disclosure provides solid forms, including a salt or co-crystal, of Compound I:which exhibits Acetyl-CoA carboxylase (“ACC”) inhibitory activity and may be useful in treating ACC mediated diseases. Also provided herein are processes or steps for the preparation of a Compound I and intermediates useful for the processes or steps described herein.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for preparing a compound of formula (N): comprising: (a) contacting a compound of formula (P): or a solvate or a hydrate thereof, with a ketoreductase under conditions sufficient to form a compound of formula (V): and (b) contacting a compound of formula (V) with a base under conditions sufficient to form a compound of formula (N), wherein R 4 is C 1-3 alkyl and R 5 is an optionally substituted C 1-6 alkyl or an optionally substituted C 6 aryl. 2. The method of claim 1 , wherein R 4 is methyl. 3. The method of claim 1 , wherein R 5 is ethyl.
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- What does patent US11279710B2 cover?
- The present disclosure provides solid forms, including a salt or co-crystal, of Compound I:which exhibits Acetyl-CoA carboxylase (“ACC”) inhibitory activity and may be useful in treating ACC mediated diseases. Also provided herein are processes or steps for the preparation of a Compound I and intermediates useful for the processes or steps described herein.
- Who is the assignee on this patent?
- Gilead Sciences Inc
- What technology area does this patent fall under?
- Primary CPC classification C07C51/09. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).