Fluidic channels for microfluidic devices

Patent metadata

Field	Value
Publication number	US-11278891-B2
Application number	US-201515763402-A
Country	US
Kind code	B2
Filing date	Sep 25, 2015
Priority date	Sep 25, 2015
Publication date	Mar 22, 2022
Grant date	Mar 22, 2022

Abstract

Example fluidic channels for microfluidic devices are disclosed. In examples disclosed herein, an example microfluidic device includes a body having a microfluidic network. The microfluidic network includes a main fluid channel to transport a biological fluid from a first cavity of the microfluidic network to a second cavity of the microfluidic network. An auxiliary fluid channel is in fluid communication with to the main fluid channel. The auxiliary fluid channel has a first end and a second end. The first end is in fluid communication with the main fluid channel and the second end is spaced from the main fluid channel. A fluid actuator is positioned in the auxiliary fluid channel to induce fluid flow in the main fluid channel.

First claim

What is claimed is:

1. A microfluidic device comprising:
a body having a microfluidic network, the microfluidic network including:
a main liquid channel to transport a liquid from a first cavity of the microfluidic network to a second cavity of the microfluidic network, wherein the main liquid channel does not contain a fluid actuator;
an auxiliary liquid channel in fluid communication with the main liquid channel, the auxiliary liquid channel having a first end and a second end, the first end in fluid communication with the main liquid channel and the second end being spaced from the main liquid channel and the second end being a blind ending that is a capped end without any structure comprising an outlet; and
a fluid actuator positioned in the auxiliary liquid channel to induce liquid flow in the main liquid channel, wherein the auxiliary liquid channel is positioned at an angle relative to the main liquid channel such that a longitudinal axis of the auxiliary liquid channel is non-parallel and non-perpendicular relative to a longitudinal axis of a main flow passageway defined by the main liquid channel.

2. The device as defined in claim 1 , wherein the fluid actuator is positioned closer to the second end of the auxiliary liquid channel than to the first end of the auxiliary liquid channel.

3. The device as defined in claim 1 , wherein the auxiliary liquid channel contains the only fluid actuator inducing liquid to flow through the main liquid channel and is positioned asymmetrically relative to an overall length of the main liquid channel and is configured to induce a unidirectional fluid flow in the main liquid channel.

4. The device as defined in claim 1 , wherein the main liquid channel comprises a device to analyze biological fluid.

5. The device of claim 1 , comprising a plurality of auxiliary liquid channels in fluid communication with the main liquid channel.

6. The device of claim 5 , wherein channels of plurality of auxiliary liquid channels are located on a shared side of the main liquid channel.

7. The device of claim 5 wherein two auxiliary liquid channels are located, respectively, at different ends of the main liquid channel and are located symmetrically with respect to a center of the main liquid channel.

8. The device of claim 1 , wherein the auxiliary liquid channel is positioned at a substantially 45 degree angle relative to the main liquid channel.

9. The device of claim 1 , wherein the first cavity and the second cavity each extend above and below the main liquid channel.

10. The device of claim 1 , wherein the first and second cavities each have a volume capacity greater than a volume capacity of the main liquid channel.

11. The device of claim 1 , wherein the fluid actuator is positioned between approximately 50 and 150 micrometers from the first end of the auxiliary liquid channel.

12. The device of claim 1 , wherein the second end of the auxiliary liquid channel is closer to a centerline of the main liquid channel than the first end of the auxiliary liquid channel.

13. A method for forming the microfluidic device of claim 1 , the method comprising:
positioning the fluid actuator adjacent the main liquid channel, the fluid actuator located in the auxiliary liquid channel;
orienting a first end of the fluid actuator in fluid communication with the main flow passageway of the main liquid channel;
projecting a second end of the fluid actuator in a direction away from the main flow passageway of the main liquid channel; and
wherein the fluid actuator is within the auxiliary liquid channel between the first end of the auxiliary liquid channel and the second end of the auxiliary liquid channel.

14. The method of claim 13 , wherein the auxiliary liquid channel is at an angle of approximately between 10 degrees and 85 degrees relative to the main liquid channel.

15. The method of claim 13 , wherein the auxiliary liquid channel is situated asymmetrically relative to an overall length of the main liquid channel.

16. A microfluidic device comprising:
a body having a microfluidic network, the microfluidic network including:
a main liquid channel to transport a liquid from a first cavity of the microfluidic network to a second cavity of the microfluidic network, wherein the main liquid channel does not contain a fluid actuator;
a plurality of auxiliary liquid channels in fluid communication with the main liquid channel, each auxiliary liquid channel having a first end and a second end, the first end in fluid communication with the main liquid channel and the second end being spaced from the main liquid channel and the second end being a blind ending that is a capped end having no outlet; and
a fluid actuator positioned in at least one auxiliary liquid channel to induce liquid flow in the main liquid channel, wherein the at least one auxiliary liquid channel is positioned at an angle relative to the main liquid channel such that a longitudinal axis of the auxiliary liquid channel is non-parallel and non-perpendicular relative to a longitudinal axis of a main flow passageway defined by the main liquid channel;
wherein some of the auxiliary liquid channels are located on opposite sides of the main liquid channel.

17. A microfluidic device comprising:
a body having a microfluidic network, the microfluidic network including:
a main liquid channel to transport a liquid from a first cavity of the microfluidic network to a second cavity of the microfluidic network, wherein the main liquid channel does not contain a fluid actuator;
an auxiliary liquid channel in fluid communication with the main liquid channel, the auxiliary liquid channel having a first end and a second end, the first end in fluid communication with the main liquid channel and the second end being spaced from the main liquid channel and the second end being a blind ending that is a capped end having no outlet; and
a fluid actuator positioned in the auxiliary liquid channel to induce liquid flow in the main liquid channel, wherein the auxiliary liquid channel is positioned at an angle relative to the main liquid channel such that a longitudinal axis of the auxiliary liquid channel is non-parallel and non-perpendicular relative to a longitudinal axis of a main flow passageway defined by the main liquid channel;
wherein the first and second cavities are different portions of a single reservoir and the main liquid channel fluidly connects to the two different portions of the single reservoir, the auxiliary liquid channel extending from a corner of the main liquid channel where the main liquid channel changes direction.

Assignees

• Hewlett Packard Development Co

Inventors

• Govyadinov Alexander
• Torniainen Erik D
• Kornilovich Pavel
• Markel David P

Classifications

• B01L3/502707

  characterised by the manufacture of the container or its components · CPC title

• B01L2400/0436

  acoustic forces, e.g. surface acoustic waves [SAW] · CPC title

• B01L2400/0442

  thermal energy, e.g. vaporisation, bubble jet · CPC title

• B01F33/30

  Micromixers · CPC title

• B01L2300/0861

  Configuration of multiple channels and/or chambers in a single devices · CPC title