Surface coatings
US-2018093019-A1 · Apr 5, 2018 · US
US11278649B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11278649-B2 |
| Application number | US-201916712582-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 12, 2019 |
| Priority date | Oct 3, 2016 |
| Publication date | Mar 22, 2022 |
| Grant date | Mar 22, 2022 |
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Described herein are substrate coatings.
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We claim: 1. An implantable device, including a surface having a coating, wherein the coating includes: a polydopamine coating deposited on the surface, wherein the polydopamine coating is formed from at least one dopamine or dopamine-like compound; and a coating deposited on the polydopamine coating, wherein the coating deposited on the polydopamine coating is formed from at least one primary amine zwitterion. 2. The implantable device of claim 1 , wherein the dopamine or dopamine-like compound increases positive charge on the implantable device. 3. The implantable device of claim 1 , wherein the dopamine or dopamine-like compound increases negative charge on the implantable device. 4. The implantable device of claim 1 , wherein the coating induces a faster occlusion time when compared to a non-coated device. 5. The implantable device of claim 1 , wherein the implantable device is a flat coupon, a hypo tube, a wire, a woven wire, a stent, or a laser cut object. 6. The implantable device of claim 1 , wherein the implantable device is a stent. 7. The implantable device of claim 1 , wherein the coating further includes a diamine, multifunctional amine, or multifunctional amine polymer. 8. The implantable device of claim 1 , wherein the at least one primary amine zwitterion includes a phosphate-containing primary amine zwitterion. 9. The implantable device of claim 1 , wherein the at least one dopamine or dopamine-like compound includes or a combination thereof. 10. The implantable device of claim 1 , wherein the at least one primary amine zwitterion includes phosphorylethanolamine. 11. The implantable device of claim 1 , wherein the at least one primary amine zwitterion includes taurine. 12. The implantable device of claim 1 , wherein the coating deposited on the polydopamine coating includes 13. The implantable device of claim 1 , wherein the coating deposited on the polydopamine coating includes 14. The implantable device of claim 1 , wherein the coating deposited on the polydopamine coating includes 15. The implantable device of claim 1 , wherein the coating includes or a combination thereof. 16. The implantable device of claim 1 , wherein the coating includes a phosphoramidate. 17. The implantable device of claim 1 , wherein the coating deposited on the polydopamine coating includes a phosphorylcholine polymer. 18. The implantable device of claim 1 , wherein the polydopamine coating is covalently deposited on the surface. 19. The implantable device of claim 1 , wherein the coating deposited on the polydopamine coating is covalently deposited on the polydopamine coating.
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