Immunity induction promoting composition, and vaccine pharmaceutical composition

Patent metadata

Field	Value
Publication number	US-11278616-B2
Application number	US-201615932118-A
Country	US
Kind code	B2
Filing date	Aug 3, 2016
Priority date	Aug 6, 2015
Publication date	Mar 22, 2022
Grant date	Mar 22, 2022

Abstract

The present invention provides an immunity induction-promoting composition which has a track record of use as a medicine or medicinal additive and is capable of safely and effectively inducing cellular immune response, and a vaccine pharmaceutical composition containing the immunity induction-promoting composition. The present invention relates to an immunity induction-promoting composition containing an immunity induction promoter whose active ingredient is an antimicrobial drug.

First claim

The invention claimed is:

1. A vaccine pharmaceutical composition for immunity induction comprising:
an antigen;
an immunity induction-promoting composition comprising an antimicrobial drug; and
a helper peptide,
wherein
the antimicrobial drug is at least one selected from a compound that has antifungal activity and a compound that has antiviral activity; and
the compound that has antifungal activity has a griseofulvin skeleton and/or an azole skeleton, and
the compound that has antiviral activity has a purine skeleton and/or an adamantane skeleton.

2. The vaccine pharmaceutical composition for immunity induction according to claim 1 ,
wherein
the compound having a griseofulvin skeleton is griseofulvin,
the compound having an azole skeleton is miconazole,
the compound having a purine skeleton is vidarabine, and
the compound having an adamantane skeleton is amantadine.

3. The vaccine pharmaceutical composition for immunity induction according to claim 1 , wherein the helper peptide is selected from Peptide-25, Peptide-25B, and PADRE.

4. The vaccine pharmaceutical composition for immunity induction according to claim 2 , wherein the helper peptide is selected from Peptide-25, Peptide-25B, and PADRE.

Assignees

• Nitto Denko Corp

Inventors

• Matsushita Kyohei
• Asari Daisuke
• Shishido takuya
• Hori Mitsuhiko

Classifications

• A61K39/00

  Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53) · CPC title

• A61P37/04 Primary

  Immunostimulants · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61K45/00

  Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00 · CPC title

• A61K2039/55511

  Organic adjuvants · CPC title