Lactobacillus paracasei AO356 strain having anti-obesity activity and method for preventing, alleviating or treating obesity using the same

Patent metadata

Field	Value
Publication number	US-11278579-B2
Application number	US-202016903955-A
Country	US
Kind code	B2
Filing date	Jun 17, 2020
Priority date	Jun 17, 2020
Publication date	Mar 22, 2022
Grant date	Mar 22, 2022

Abstract

A novel Lactobacillus paracasei AO356 strain according to the present disclosure, which is a strain isolated from the human body, has high stability, exhibits the activity of inhibiting adipogenic differentiation in vitro and inducing the differentiation of M1 and M0 macrophages into M2 macrophages, and has excellent activity of alleviating, preventing, or treating obesity, such as the activity of reducing body weight and a reduction in blood lipid concentration through the browning of white fat in animal experiments. Thus, the novel strain of the present disclosure has a low possibility of causing side effects, and therefore, unlike conventional diet functional foods or drugs, which have side effect problems, a diet effect can be exhibited without controlling the dose thereof. Accordingly, the novel strain can be used as a pharmaceutical composition for treating or preventing obesity or a food composition for alleviating or preventing obesity.

First claim

What is claimed is:

1. A method of inhibiting weight gain in a mammalian subject in need thereof comprising orally administering to said subject a composition comprising an effective dose of the isolated Lactobacillus paracasei AO356 strain that is deposited as KCCM12145P, wherein the Lactobacillus paracasei AO356 strain has a 16S rDNA consisting of SEQ ID NO: 1.

2. The method of claim 1 , wherein the composition is a pharmaceutical composition comprising 5×10 3 CFU to 5×10 7 CFU of the Lactobacillus paracasei AO356 strain.

3. The method of claim 1 , wherein the Lactobacillus paracasei AO356 strain exhibits anti-obesity activity and adipogenesis inhibitory activity.

4. The method of claim 1 , wherein the composition is a food composition comprising 5×10 3 CFU to 5×10 7 CFU of the Lactobacillus paracasei AO356 strain.

5. The method of claim 1 , wherein the Lactobacillus paracasei AO356 strain is alive or dead.

6. The method of claim 2 , wherein the composition comprises a pharmaceutically acceptable carrier.

Assignees

• Korea Food Res Inst

Inventors

• Nam Young Do
• Lee So Young
• Shin Hee Soon
• Park So Lim
• Chung Won Hyong
• Lee Eun Sook
• Song Eun Ji
• Shin Dong Uk

Classifications

• C12N1/205

  Bacterial isolates · CPC title

• A61K2035/115

  Probiotics · CPC title

• A61K35/742 Primary

  Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes · CPC title

• C12R2001/225

  Lactobacillus · CPC title

• A61K35/747

  Lactobacilli, e.g. L. acidophilus or L. brevis · CPC title