Devices, systems, and methods for the treatment of vascular defects

Patent metadata

Field	Value
Publication number	US-11278291-B2
Application number	US-201916718163-A
Country	US
Kind code	B2
Filing date	Dec 17, 2019
Priority date	Dec 17, 2018
Publication date	Mar 22, 2022
Grant date	Mar 22, 2022

Abstract

Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

First claim

We claim:

1. An occlusive device for treating an aneurysm, wherein a neck of the aneurysm opens to a blood vessel, the device comprising:
a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising—
a first end portion, a second end portion, and a length extending between the first and second end portions,
a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges,
a first side and a second side opposite the first side, and

wherein the mesh has a predetermined shape in an unconstrained, expanded state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has a plurality of undulations across at least a portion of its length, wherein the plurality of undulations comprise a first inflection region comprising a first peak at the first side and a first valley at the second side, a second infection region comprising a second valley at the first side and a second peak at the second side, and a third inflection region comprising a third peak at the first side and a third valley at the second side, and
wherein the mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm with the first side facing a cavity of the aneurysm and the second side facing the blood vessel.

2. The occlusive device of claim 1 , wherein the mesh is configured to be positioned within the aneurysm such that the second peak is convex towards the aneurysm cavity.

3. The occlusive device of claim 1 , wherein, at least in an expanded, unconstrained state, the mesh includes a crease extending along the entire width.

4. The occlusive device of claim 1 , wherein the mesh has a thickness measured between the first side and the second side, and wherein the mesh has a generally constant thickness along its length.

5. The occlusive device of claim 1 , wherein the mesh does not define an inner cavity.

6. The occlusive device of claim 1 , wherein the mesh is formed of a tubular braid that has been flattened along its longitudinal axis such that opposing portions of a sidewall of the tubular braid are urged towards one another.

7. The occlusive device of claim 1 , wherein the width of the mesh tapers in the direction of the first end portion.

8. The occlusive device of claim 1 , wherein the width of the mesh tapers in the direction of the second end portion.

9. The occlusive device of claim 1 , wherein the mesh is formed of a plurality of filaments, and wherein at least some of the filaments are drawn-filled tube (“DFT”) wires.

10. The occlusive device of claim 1 wherein a proximal end of the mesh is configured to be detachably coupled to an elongated delivery member.

11. The occlusive device of claim 1 , wherein a proximal end of the occlusive device is configured to be detachably coupled to an elongated delivery member.

12. The occlusive device of claim 1 , further comprising an embolic element coupled to a proximal end of the mesh.

13. The occlusive device of claim 1 , further comprising a lead-in member coupled to a distal end of the mesh.

14. The occlusive device of claim 1 , wherein a radius of curvature of the mesh increases distally along its longitudinal axis between its proximal and distal ends.

15. The occlusive device of claim 1 wherein a radius of curvature of the mesh decreases distally along its longitudinal axis between its proximal and distal ends.

16. The occlusive device of claim 1 , wherein a radius of curvature of the mesh is generally constant along its longitudinal axis between its proximal and distal ends.

17. The occlusive device of claim 1 , wherein, when the occlusive device is positioned in the aneurysm, the proximal end of the mesh does not overlap the distal end of the mesh.

18. An occlusive device for treating an aneurysm, wherein a neck of the aneurysm opens to a blood vessel, the device comprising:
a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising—
a first end portion, a second end portion, and a length extending between the first and second end portions, and
a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges; and

an elongated embolic element coupled to the mesh;
wherein the mesh has a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has a first region, a second region, and a third region extending along its length, the second region being disposed between the first and third regions, and
wherein the occlusive device is configured to be positioned within the aneurysm such that the mesh extends over the neck of the aneurysm and the elongated embolic element is positioned between a dome of the aneurysm and the mesh, and
wherein, when the mesh is in the deployed state and positioned within the aneurysm with the mesh positioned across the neck of the aneurysm, the first and third regions of the mesh are concave towards the dome of the aneurysm and the second region of the mesh is convex towards the dome of the aneurysm.

19. The occlusive device of claim 18 , wherein the mesh and the embolic element are coupled end-to-end.

20. The occlusive device of claim 18 , wherein the mesh and the embolic element are coupled end-to-end and such that, when positioned within a delivery catheter for intravascular delivery to the aneurysm, the mesh is distal of the embolic element in the delivery catheter so that the mesh is delivered to the aneurysm before the embolic element.

21. The occlusive device of claim 18 , wherein the embolic element is a coil.

22. The occlusive device of claim 18 , wherein the embolic element and the mesh are coupled at a joint, and wherein the embolic element and the mesh are configured to bend and twist relative to one another at the joint.

23. The occlusive device of claim 22 , wherein the first end portion of the mesh includes a band, and wherein an end portion of the embolic element is positioned over at least a portion of the band at the joint.

Assignees

• Covidien Lp

Inventors

• Hamel Gregory
• Quinn Patrick
• Rosqueta Arturo
• Sosnowski Stephen
• Andrews Christopher
• Dang Hieu
• Nguyen Dinh
• Pecor Robert
• Dinh Minh Q
• Tatavoosian Ahramahzd

Classifications

• A61B17/12177

  comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated · CPC title

• A61B17/12118

  for positioning in conjunction with a stent · CPC title

• A61B17/12113 Primary

  within an aneurysm · CPC title

• A61B17/12145

  having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526) · CPC title

• A61B2017/00526

  Methods of manufacturing · CPC title