Phosphor composition having selected surface coatings

Patent metadata

Field	Value
Publication number	US-11278042-B2
Application number	US-202017135479-A
Country	US
Kind code	B2
Filing date	Dec 28, 2020
Priority date	Mar 15, 2013
Publication date	Mar 22, 2022
Grant date	Mar 22, 2022

Abstract

A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

First claim

The invention claimed is:

1. A method for producing a change in a medium or body, comprising:
(1) placing in a vicinity of the medium or body at least one energy modulation agent configured to emit radiation into the medium or body upon interaction with an initiation energy; and
(2) applying the initiation energy from an energy source to the medium or body,
wherein the applied initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium or body by said emitted radiation,
wherein said energy modulation agent has a normal predominant emission of radiation in a first wavelength range (WR1) outside of a second wavelength range (WR2) known to produce said change, but under exposure to said applied initiation energy produces said change, and
wherein said energy modulation agent is coupled to a carrier for targeting the energy modulation agent to a specific target region of the medium or body.

2. The method of claim 1 , wherein the carrier is a member selected from the group consisting of proteins, lipids, chitins, chitin derivatives, and chelates.

3. The method of claim 1 , wherein the normal predominant emission of the energy modulation agent is in the visible-light wavelength range and said wavelength range WR2 is in the ultraviolet range.

4. The method of claim 3 , wherein the normal predominant emission of the energy modulation agent is characterized by visible emissions in at least one of the red, yellow, orange, green, blue, and not in the ultraviolet range.

5. The method of claim 3 , wherein the energy modulation agent emits said radiation in WR2.

6. The method of claim 5 , wherein the energy modulation agent emits said radiation in the ultraviolet range.

7. The method of claim 1 , wherein the energy modulation agent comprises at least one phosphor or a combination of two or more phosphors.

8. The method of claim 7 , wherein the energy modulation agent comprises a mixture of three phosphors.

9. The method of claim 1 , further comprising a plasmonics agent configured to 1) enhance or modify said light from the energy modulation agent or 2) enhance or modify the initiation energy.

10. The method of claim 1 , wherein applying comprises applying the initiation energy to activate a photoactivatable agent.

11. The method of claim 10 , wherein the photoactivatable agent is selected from psoralens, pyrene cholesteryloleate, acridine, porphyrin, fluorescein, rhodamine, 16-diazorcortisone, ethidium, transition metal complexes of bleomycin, transition metal complexes of deglycobleomycin organoplatinum complexes, alloxazines, vitamin Ks, vitamin L, vitamin metabolites, vitamin precursors, naphthoquinones, naphthalenes, naphthols and derivatives thereof having planar molecular conformations, porphorinporphyrins, dyes and phenothiazine derivatives, coumarins, quinolones, quinones, and anthroquinones.

12. The method of claim 11 , wherein the photoactivatable agent comprises a photocaged drug, a psoralen, a coumarin, or a derivative thereof.

13. The method of claim 12 , wherein at least one of a cancer cell, a tumor cell, an autoimmune disorder, a virus, or a blood-borne germicide is treated by the photocaged drug, the psoralen, the coumarin, or the derivative thereof.

14. The method of claim 1 , wherein the change produced is treatment of a cell proliferation disorder in a subject in need thereof.

15. The method of claim 1 , wherein applying comprises:
applying the initiation energy to an uncured radiation-curable medium to thereby cure the uncured radiation-curable medium;
applying the initiation energy to a structure in which a gap therein was prefilled with an uncured radiation-curable medium to thereby cure the uncured radiation-curable medium in the gap; or
applying the initiation energy to produce a patterned element from the uncured radiation-curable medium.

16. The method of claim 1 , wherein applying comprises applying said initiation energy from a source emitting at least one of x-rays, gamma rays, and an electron beam.

17. The method of claim 1 , further comprising a plasmonics agent including a metallic structure.

18. The method of claim 17 , wherein the metallic structure comprises at least one of nanospheres, nanorods, nanocubes, nanopyramids, nanoshells, multi-layer nanoshells, and combinations thereof.

19. The method of claim 1 , wherein the energy modulation agent comprises at least one of a sulfide, a telluride, a selenide and an oxide semiconductor and a combination thereof.

20. The method of claim 1 , wherein the energy modulation agent comprises at least one of CaWO 4 :Pb 2+ , CaWO 4 :W, Sr 3 (PO 4 ) 2 :Eu 2+ , Ba 3 (PO 4 ) 2 :Eu 2+ , Y 2 SiO 5 :Ce 3+ , SrMg(SiO 4 ) 2 :Eu 2+ , BaMg 2 Al 14 O 24 :Eu 2+ , ZnSiO 4 :Mn 2+ , Y 3 (Al,Ga) 5 O 12 :Ce 3+ , BaMg 2 Al 14 O 24 :Mn 2+ , BaMgAl 14 O 23 :Mn 2+ , SrAl 12 SiO 19 :Mn 2+ , ZnAl 12 O 19 :Mn 2+ , CaAl 12 O 19 :Mn 2+ , YBO 3 :Tb 3+ , Sr 4 Si 3 O 8 Cl 4 :EU 3+ , Y 2 O 3 :EU 3+ , Y 2 SiO 5 :EU 3+ , Y 3 Al 5 O 12 Eu 3+ , CaSiO 3 :Mn 2+ ,YVO 4 :Eu 3+ .

21. The method of claim 1 , further comprising:
a plasmonics agent comprising a dielectric-metal composite; or
a plasmonics agent comprising a plurality of differently sized metal particles disposed in vicinity of each other as a composite plasmonics agent.

22. The method of claim 1 , wherein the change in the medium comprises a change in organism activity.

23. The method of claim 22 , wherein the change in activity comprises at least one of a sterilization of the medium or a deactivation of fermentation in the medium.

24. The method of claim 22 , wherein the change in activity comprises a cold pasteurization of the medium.

25. The method of claim 1 , wherein applying comprises sterilizing a medium including at least one organism selected from the group consisting of bacteria, viruses, yeasts, and fungi.

26. The method of claim 1 , further comprising introducing a photoactivatable agent to the medium.

27. The method of claim 26 , wherein the photoactivatable agent comprises an active agent contained within a photocage, configured such that upon exposure to said emitted radiation, the photocage releases the active agent into the medium.

28. The method of claim 26 , wherein the photoactivatable agent comprises a photocatalyst.

29. The method of claim 26 , wherein the photocatalyst agent comprises at least one of TiO 2 , ZnO, CdS, CdSe, SnO 2 , SrTiO 3 , WO 3 , Fe 2 O 3 , and Ta 2 O 5 .

30. The method of claim 1 , wherein applying comprises:
applying the initiation energy throughout an entire volume of an artificial container.

31. The method of claim 30 , wherein applying comprises:
transmitting the initiation energy through said artificial container comprising at least one of an aluminum container, a quartz container, a glass container, a plastic container or a combination thereof.

32. The method of claim 1 , wherein the energy modulation agent is provided within the medium at a density where said light generated in the medium from the energy modulation agent is not occluded throughout the medium.

33. The method of claim 1 , further comprising providing segregated within the medium the energy modulation agents.

34. The method of claim 33 , wherein providing segregated within

Assignees

• Immunolight Llc

Inventors

• Bourke Jr Frederic A
• Fathi Zakaryae
• Walder Harold
• Beyer Jr Wayne F

Classifications

• A61L2103/15

  Laboratory, medical or dentistry appliances, e.g. catheters or sharps · CPC title

• A61L2/10

  Ultraviolet [UV] radiation · CPC title

• A61L2/082

  X-rays · CPC title

• A61L2103/05

  Living organisms or biological materials · CPC title

• A23B2/503

  with corpuscular or ionising radiation, i.e. X, alpha, beta or omega radiation · CPC title