Antibiotic compounds

Patent metadata

Field	Value
Publication number	US-11278025-B2
Application number	US-201816614251-A
Country	US
Kind code	B2
Filing date	May 17, 2018
Priority date	May 17, 2017
Publication date	Mar 22, 2022
Grant date	Mar 22, 2022

Abstract

The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.

First claim

What is claimed is:

1. A compound of Formula (II):

or a pharmaceutically acceptable salt thereof, wherein:
L 2 is C 1-3 alkylene;
each Hal is independently a halogen;
R 2a , R 3a , R 4a , and R 5a are each independently selected from H and OH;
provided that at least one of R 2a , R 3a , R 4a , and R 5a is OH; and
R 2b , R 3b , R 4b , R 5b , R 6b , and R 7b are each independently selected from H, OH, HO—C 1-3 alkylene, and —C(═O)OH.

2. The compound of claim 1 having any one of the following formulae:

or pharmaceutically acceptable salt thereof, wherein:
wherein R 2b , R 3b , R 4b , R 5b , R 6b , and R 7b are each independently selected from H, OH, and —C(═O)OH.

3. The compound of claim 1 , wherein the compound of Formula (II) is selected from:

or a pharmaceutically acceptable salt thereof.

4. A compound having a formula:

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 , having formula:

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 , having formula:

or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 , having formula:

or a pharmaceutically acceptable salt thereof.

Assignees

• Massachusetts Gen Hospital
• Rhode Island Hosp Lifespan Ptr
• Univ Temple

Inventors

• Ausubel Frederick M
• Kim Wooseong
• Mylonakis Eleftherios
• Wuest William M

Classifications

• A61K31/192

  having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid  {(cannabinoids A61K31/658)} · CPC title

• A61K31/05

  Phenols {(cannabinoids A61K31/658)} · CPC title

• A01N31/08 Primary

  Oxygen or sulfur directly attached to an aromatic ring system · CPC title

• C07C65/17 Primary

  containing rings other than six-membered aromatic rings · CPC title

• C07C235/68

  having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced · CPC title