Membrane for blood purification

Patent metadata

Field	Value
Publication number	US-11273416-B2
Application number	US-202016851432-A
Country	US
Kind code	B2
Filing date	Apr 17, 2020
Priority date	Feb 6, 2014
Publication date	Mar 15, 2022
Grant date	Mar 15, 2022

Abstract

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

First claim

The invention claimed is:

1. A membrane comprising i) at least one hydrophobic polymer component and ii) at least one hydrophilic polymer component, wherein the membrane has a molecular retention onset (MWRO) of between 9.0 kDa and 14.0 kDa and a molecular weight cut-off (MWCO) of between 55 kDa and 130 kDa as determined by dextran sieving before blood contact of the membrane.

2. The membrane of claim 1 , wherein the membrane is a hollow fiber membrane.

3. The membrane of claim 1 , wherein the membrane is a flat sheet fiber membrane.

4. The membrane of claim 1 , wherein the hydrophobic polymer component is poly(aryl)ethersulfone (PAES).

5. The membrane of claim 1 , wherein the hydrophilic polymer component is polyvinylpyrrolidone (PVP).

6. The membrane of claim 1 , wherein the hydrophobic polymer component is poly(aryl)ethersulfone (PAES) and the hydrophilic polymer component is polyvinylpyrrolidone (PVP), and
wherein the membrane comprises between 2.0 wt.-% to 4.0 wt.-% PVP and a balance of poly(aryl)ethersulfone adding up to 100%.

7. The membrane of claim 4 , wherein the membrane comprises a second hydrophobic polymer component.

8. The membrane of claim 7 , wherein the second hydrophobic polymer component is polyamide.

9. The membrane of claim 2 , wherein the hollow fiber membrane comprises a wall thickness from 30 μm to 49 μm.

10. The membrane of claim 2 , wherein the hollow fiber membrane comprises a wall thickness from 30 μm to 40 μm.

11. The membrane of claim 2 , wherein the hollow fiber membrane comprises an inner diameter from 170 μm to 200 μm.

12. The membrane of claim 2 , wherein the hollow fiber membrane comprises an inner diameter from 175 μm to 185 μm.

13. The membrane of claim 1 , wherein the membrane has a molecular retention onset (MWRO) of between 9.0 kDa and 12.5 kDa and a molecular weight cut-off (MWCO) of between 68 kDa and 110 kDa as determined by dextran sieving before blood contact of the membrane.

14. The membrane of claim 1 , wherein the membrane has a molecular retention onset (MWRO) of between 10.0 kDa and 12.5 kDa and a molecular weight cut-off (MWCO) of between 68 kDa and 90 kDa as determined by dextran sieving before blood contact of the membrane.

15. The membrane of claim 1 , wherein the membrane has a molecular retention onset (MWRO) of between 10.0 kDa and 12.5 kDa and a molecular weight cut-off (MWCO) of between 65 kDa and 90 kDa as determined by dextran sieving before blood contact of the membrane.

16. The membrane of claim 1 , wherein the membrane has an asymmetric finger-like structure comprising at least three layers,
wherein the first layer is a separation layer,
wherein the second layer is a sponge structure, and
wherein the third layer is a finger structure.

17. The membrane of claim 16 , wherein the first layer has a thickness of less than 0.5 μm.

18. The membrane of claim 16 , wherein the second layer has a thickness of about 1 μm to 15 μm.

19. The membrane of claim 16 , wherein the third layer has a thickness of 20 μm to 30 μm.

20. The membrane of claim 16 , wherein the membrane further comprises a fourth layer, wherein the fourth layer is an outer surface.

Assignees

• Gambro Lundia Ab

Inventors

• Boschetti-De-Fierro Adriana
• Voigt Manuel
• Krause Bernd
• Hornung Markus
• Storr Markus
• Behr Heinrich
• Beck Werner
• Zweigart Carina
• Buck Reinhold
• Herbst Philipp
• Loercher Joachim
• Wochner Arnd

Classifications

• B01D69/087 Primary

  Details relating to the spinning process · CPC title

• B01D63/0233

  forming the bundle · CPC title

• B01D71/441

  Polyvinylpyrrolidone · CPC title

• B01D71/381

  Polyvinylalcohol · CPC title

• B01D61/243

  Dialysis · CPC title