Autologous pleurodesis methods and devices

Patent metadata

Field	Value
Publication number	US-11273292-B2
Application number	US-201916243569-A
Country	US
Kind code	B2
Filing date	Jan 9, 2019
Priority date	Dec 23, 2013
Publication date	Mar 15, 2022
Grant date	Mar 15, 2022

Abstract

System and components for inducing pleurodesis or other sclerosis or desired adhesion conditions to treat a patient, while minimizing likelihood of tissue damage from direct application of sclerosis-enhancing materials. A tube device is provided that is configured to elute sclerosis-enhancing material and/or other medicaments including autologous or otherwise patient compatible blood and/or blood component(s) via an assembly including fenestrated drainage tube which may be a multi-lumen assembly allowing simultaneous infusion/elution and drainage. The assembly of tube device with outer (typically drainage) tube may include one or more features configured to enhance delivery of medicament and/or drainage through the same assembly.

First claim

We claim:

1. A catheter assembly configured for drainage and for blood-induced pleurodesis inducement, the assembly comprising:
an elongate flexible first tube body comprising a distal length configured to indwell a patient body trunk cavity from and distal of a sealing cuff that is configured to contact sealingly with a patient's body wall;
at least one first tube body lumen extending longitudinally through a lengthwise portion of the distal length, the at least one first tube body lumen substantially defined by an inner diameter surface of the first tube body;
the distal length including at least one fenestration providing fluid communication between the first tube body lumen and a region external of the first tube body;
wherein the at least one first tube body lumen comprises a plurality of lumens that extend through a length of the first tube body, with at least one lumen configured for medicament infusion and at least one lumen configured for drainage, the first tube body comprising the distal length that is unitary and unsplit and a split region that splits the first tube body into at least two branches such that the first tube body forms the split region, the distal length and the at least two branches, wherein the at least one lumen configured for medicament infusion extends through one of the at least two branches and the at least one lumen configured for drainage extends through another of the at least two branches;
a first valve connected to the one of the at least two branches in communication with the at least one lumen configured for drainage, the first valve configured to interface with a drainage modality; and
a second valve connected to the another of the at least two branches and in communication with the at least one lumen configured for medicament infusion, the second valve configured to interface with an infusion assembly.

2. The catheter assembly of claim 1 , wherein at least one portion of the distal length is configured as an injection portion that includes at least one surface and/or a further opening constructed to permit passage therethrough of a sclerotic agent.

3. The catheter assembly of claim 1 , wherein, in a first state, a second tube body is removably attached to the second valve at a distal end of the second tube body, and in the first state, a proximal end of the second tube body is disposed in fluid communication with a blood supply.

4. The catheter assembly of claim 3 , wherein, in a second state, the proximal end of the second tube body is not disposed in fluid communication with a blood supply.

5. The catheter assembly of claim 4 , wherein, in a third state, a vacuum bottle or other drainage modality is attached in fluid communication with the first tube body using the first valve.

6. A catheter assembly apparatus for autologous blood transfer to a target region within a patient's body, the apparatus comprising:
a drainage modality configured for receiving fluid from the patient's body;
an infusion assembly configured for supplying a medicament to the patient's body;
a catheter assembly comprising:
an elongate flexible first tube body comprising a distal length configured to indwell a patient body trunk cavity from and distal of a sealing cuff that is configured to contact sealingly with a patient's body wall;
at least one first tube body lumen extending longitudinally through a lengthwise portion of the distal length, the at least one first tube body lumen substantially defined by an inner diameter surface of the first tube body;
the distal length including at least one fenestration providing fluid communication between the first tube body lumen and a region external of the first tube body;
wherein the at least one first tube body lumen comprises a plurality of lumens that extend through a length of the first tube body, with at least one lumen configured for medicament infusion and at least one lumen configured for drainage, the first tube body comprising the distal length that is unitary and unsplit and a split region that splits the first tube body into at least two branches such that the first tube body forms the split region, the distal length and the at least two branches, wherein the at least one lumen configured for medicament infusion extends through one of the at least two branches and connects to the infusion assembly and the at least one lumen configured for drainage extends through another of the at least two branches and connects to the drainage modality;
a first valve connected to the one of the at least two branches in communication with the at least one lumen configured for drainage, the first valve configured to interface with the drainage modality; and
a second valve connected to the another of the at least two branches and in communication with the at least one lumen configured for medicament infusion, the second valve configured to interface with the infusion assembly.

7. The apparatus of claim 6 , wherein at least one portion of the distal length is configured as an injection portion that includes at least one surface and/or a further opening constructed to permit passage therethrough of a sclerotic agent.

8. The apparatus of claim 7 , wherein, in a first state, a second tube body of the catheter assembly is removably attached to the second valve at a distal end of the second tube body, and in the first state, a proximal end of the second tube body is disposed in fluid communication with a blood supply.

9. The apparatus of claim 8 , wherein, in a second state, the proximal end of the second tube body is not disposed in fluid communication with a blood supply using the first valve.

10. A method of delivering a medicament via a catheter assembly in a body lumen, the method comprising:
directing a distal portion including the distal length of the first tube body of the catheter assembly of claim 1 into a body cavity;
directing the distal portion to a target site;
dispensing the medicament to the target site through the at least one lumen configured for medicament infusion.

11. The method of claim 10 , wherein the medicament comprises one or more of a sclerosing agent, a therapeutic agent, an effervescent material, a radiopaque material, whole blood and blood components.

12. The method of claim 10 , wherein the first tube body comprises a lubricious coating configured to resist adhesion by a medicament.

13. The method of claim 10 further comprising connecting the first valve to the at least one lumen configured for drainage.

14. The method of claim 10 further comprising connecting the second valve to the at least one lumen configured for medicament infusion with an infusion assembly.

Assignees

• Carefusion 2200 Inc

Inventors

• Devries Elise
• Krueger John
• Massi Shayna
• Ray John
• Doshi Palak

Classifications

• A61M25/0041

  pre-formed, e.g. specially adapted to fit with the anatomy of body channels (urethral catheters A61F2/04) · CPC title

• A61M2205/0266

  Shape memory materials · CPC title

• A61M25/0606

  "Over-the-needle" catheter assemblies, e.g. I.V. catheters · CPC title

• A61M25/0045

  multi-layered, e.g. coated (coating materials A61L29/08) · CPC title

• A61B90/39

  Markers, e.g. radio-opaque or breast lesions markers · CPC title