Composition comprising a polymeric reagent
US-2019046651-A1 · Feb 14, 2019 · US
Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
US11266742B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11266742-B2 |
| Application number | US-202016878401-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 19, 2020 |
| Priority date | Jun 16, 2005 |
| Publication date | Mar 8, 2022 |
| Grant date | Mar 8, 2022 |
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Abstract
Official abstract text for this publication.
The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A conjugate having a structure: wherein each m-PEG is a methoxy poly(ethylene glycol), and Drug is a residue of a biologically active agent comprising an amino group. 2. The conjugate of claim 1 , wherein each methoxy poly(ethylene glycol) has a weight-average molecular weight in the range of from about 120 Daltons to about 6,000 Daltons. 3. The conjugate of claim 1 , wherein each methoxy poly(ethylene glycol) has a weight-average molecular weight in the range of from about 6,000 Daltons to about 100,000 Daltons. 4. A pharmaceutical composition comprising the conjugate of claim 1 and a pharmaceutically acceptable excipient. 5. The pharmaceutical composition of claim 4 , in lyophilized form. 6. The pharmaceutical composition of claim 4 , further comprising a liquid diluent. 7. The pharmaceutical composition of claim 6 , wherein the liquid diluent is selected from the group consisting of bacteriostatic water for injection, dextrose 5% in water, phosphate-buffered saline, Ringer's solution, saline solution, sterile water, deionized water, and combinations thereof. 8. The pharmaceutical composition of claim 4 , in unit dosage form. 9. The conjugate of claim 1 , wherein the biologically active agent is a small molecule. 10. The conjugate of claim 1 , wherein the biologically active agent is a polypeptide. 11. A polymeric reagent of a structure: wherein each m-PEG is a methoxy poly(ethylene glycol), and (FG) is a functional group capable of reacting with an amino group of a biologically active agent.
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Classifications
Polymers modified by chemical after-treatment · CPC title
having oxygen in addition to nitrogen · CPC title
Additives improving oxygen scavenging properties · CPC title
containing nitrogen in addition to sulfur · CPC title
Glucagons · CPC title
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- What does patent US11266742B2 cover?
- The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and c…
- Who is the assignee on this patent?
- Nektar Therapeutics
- What technology area does this patent fall under?
- Primary CPC classification A61K47/60. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).