Apparatus for detecting sample properties using chaotic wave sensor

Patent metadata

Field	Value
Publication number	US-11262287-B2
Application number	US-202117142529-A
Country	US
Kind code	B2
Filing date	Jan 6, 2021
Priority date	Nov 17, 2015
Publication date	Mar 1, 2022
Grant date	Mar 1, 2022

Abstract

Provided is a sample property detecting apparatus including: a wave source configured to irradiate a wave towards a sample; a detector configured to detect a laser speckle that is generated when the wave is multiple-scattered by the sample, at every time point that is set in advance; and a controller configured to obtain a temporal correlation that is a variation in the detected laser speckle according to time, and to detect properties of the sample in real-time based on the temporal correlation, wherein the detector detects the laser speckle between the sample and the detector or from a region in the detector.

First claim

What is claimed is:

1. A virus detecting apparatus comprising:
a sample arranging portion configured to accommodate a sample;
a virus marker applier configured to apply a virus marker including a magnetic particle to the sample to form a detection complex, in which the virus marker is combined with a virus in the sample;
a magnetic field generator that is adjacent to the sample arranging portion to form a magnetic field around the sample arranging portion and move the detection complex;
a wave source configured to irradiate a wave towards the sample in the sample arranging portion;
at least one detector configured to detect a laser speckle that is generated when the irradiated wave is multiple-scattered by a movement of the detection complex, at every time point that is set in advance; and
a controller configured to obtain a temporal correlation of the detected laser speckle, by using the detected laser speckle, and estimate in real-time an existence of the virus in the sample or a concentration of the virus, based on the obtained temporal correlation.

2. The virus detecting apparatus of claim 1 , wherein the virus marker comprises an antibody bound to the virus in the sample, and the magnetic particle combined with the antibody.

3. The virus detecting apparatus of claim 2 , wherein the sample comprises a plural kinds of viruses, and
the virus marker applier is further configured to apply a plural kinds of virus markers, each including the antibody bound to one of the plural kinds of viruses and the magnetic particle combined with the antibody, to the sample.

4. The virus detecting apparatus of claim 1 , wherein the sample arranging portion supports the sample while restricting the movement of the sample.

5. The virus detecting apparatus of claim 1 , wherein the magnetic field generator makes the detection complex move by changing a direction or an intensity of the magnetic field at every predetermined first time period.

6. The virus detecting apparatus of claim 5 , wherein the controller receives magnetic field information about the changed direction or intensity of the magnetic field from the magnetic field generator, and obtains a temporal correlation of the detected laser speckle by using the magnetic field information.

7. The virus detecting apparatus of claim 5 , wherein an interval between the time points that are set in advance for the detector to perform the detection is less than the first time period.

8. The virus detecting apparatus of claim 1 , wherein the magnetic field generator uses a micro nuclear magnetic resonance (micro-NMR).

9. A virus detecting method, the method comprising:
applying a virus marker including a magnetic particle to a sample to form a detection complex in which the virus marker is combined with a virus in the sample;
forming a magnetic field around the sample to make the detection complex move;
irradiating a wave towards the sample to detect a laser speckle at every time point set in advance, the laser speckle generated when the irradiated wave is multiple-scattered by the movement of the detection complex;
obtaining a temporal correlation of the detected laser speckle by using the detected laser speckle; and
estimating in real-time an existence of the virus in the sample or a concentration of the virus in the sample based on the obtained temporal correlation.

10. The virus detecting method of claim 9 , wherein the virus marker comprises an antibody bound to the virus in the sample, and the magnetic particle combined with the antibody.

11. The virus detecting method of claim 10 , wherein the forming of the detection complex comprises applying a plural kinds of virus markers, each including the antibody bound to one of the plural kinds of viruses and the magnetic particle combined with the antibody, to the sample including the plural kinds of viruses.

12. The virus detecting method of claim 9 , wherein the movement of the sample is restricted by the sample arranging portion.

13. The virus detecting method of claim 9 , wherein the making the detection complex move comprises changing a direction or an intensity of the magnetic field at every first time period.

14. The virus detecting method of claim 13 , wherein the obtaining of the temporal correlation comprises receiving magnetic field information about the changed direction or intensity of the magnetic field, and obtaining the temporal correlation of the detected laser speckle by using the magnetic field information.

15. The virus detecting method of claim 13 , wherein in the detecting of the laser speckle, an interval between the time points that are set in advance is less than the first time period.

Assignees

• Korea Advanced Inst Sci & Tech
• The Wave Talk Inc

Inventors

• Park Yongkeun
• Yoon Jonghee
• Lee KyeoReh
• Kim Young Dug

Classifications

• G01N15/06 Primary

  Investigating concentration of particle suspensions (by weighing G01N5/00; investigating sedimentation of particle suspensions G01N15/04; investigating individual particles G01N15/10) · CPC title

• C12Q1/18

  Testing for antimicrobial activity of a material · CPC title

• G01N2015/0687

  in solutions, e.g. non volatile residue · CPC title

• G01N21/4788

  Diffraction (for sizing particles G01N15/0205) · CPC title

• G01N2021/391

  Intracavity sample · CPC title