Compositions for creatine supplementation in creatine non-responders

Patent metadata

Field	Value
Publication number	US-11260096-B2
Application number	US-202016913973-A
Country	US
Kind code	B2
Filing date	Jun 26, 2020
Priority date	Jun 28, 2019
Publication date	Mar 1, 2022
Grant date	Mar 1, 2022

Abstract

Disclosed herein are methods for creatine supplementation for human subjects, particularly creatine non-responders.

First claim

The invention claimed is:

1. A method of increasing creatine absorption in muscles in a human subject in need thereof, the method comprising co-administering to said human subject a supplemental amount of creatine, an effective amount of effective amount of creatinine, and a source of nitrate anion (NO 3 —), wherein the source of nitrate anion (NO 3 —) provides an effective amount of nitrate anion (NO 3 —).

2. The method of claim 1 , wherein the human subject is a creatine non-responder.

3. The method of claim 1 , wherein the co-administering comprises administering to the human subject a composition comprising:
the supplemental amount of creatine;
the effective amount of creatinine; and
the source of nitrate anion (NO 3 − ).

4. The method of claim 1 , wherein the supplemental amount of creatine is at least 500 mg, the effective amount of creatinine is at least 500 mg and the effective amount of the nitrate anion (NO 3 − ) is at least 50 mg.

5. The method of claim 1 , wherein the supplemental amount of creatine is at least 1000 mg, the effective amount of creatinine is at least 1000 mg, and the effective amount of nitrate anion (NO 3 − ) is at least 100 mg.

6. The method of claim 1 , wherein the supplemental amount of creatine is at least 2 grams, the effective amount of creatinine is at least 2 grams, and the effective amount of nitrate anion (NO 3 − ) is at least 500 mg.

7. The method of claim 1 , wherein the supplemental amount of creatine is at least 5 grams, the effective amount of creatinine is at least 3 grams, and the effective amount of nitrate anion (NO 3 − ) is at least 1000 mg.

8. The method of claim 1 , wherein the supplemental amount of creatine is at least between 500 mg and 20000 mg, the effective amount of creatinine is at between 500 mg and 30000 mg, and the effective amount of the nitrate anion (NO 3 − ) is at between 50 mg and 3000 mg.

Assignees

• Thermolife Int Llc

Inventors

• Kramer Ronald
• Nikolaidis Alexandros

Classifications

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61K31/198 Primary

  Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title

• A23L33/175

  Amino acids · CPC title

• A61K36/48 Primary

  Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae · CPC title