Process for preparing a powdered composition

Patent metadata

Field	Value
Publication number	US-11260001-B2
Application number	US-201816648524-A
Country	US
Kind code	B2
Filing date	Dec 13, 2018
Priority date	Dec 14, 2017
Publication date	Mar 1, 2022
Grant date	Mar 1, 2022

Abstract

The present disclosure relates to the field of delivery systems. More particularly, the present disclosure relates to a process for preparing a powdered composition including granules. The granules include at least one active substance present in an encapsulated form and in a non-encapsulated form. They are obtained by drying a mixture including an aqueous phase of a water-soluble polymer, a Pickering emulsion including a non-encapsulated active substance and a microcapsule slurry including an encapsulated active substance that can differ or being the same as the non-encapsulated substance. The disclosure further relates to granules obtained by the process and to products containing them.

First claim

The invention claimed is:

1. A process for preparing a powdered composition, said process comprising the steps of:
a) adding a solution of a water-soluble polymer to a Pickering emulsion, wherein the Pickering emulsion comprises
(i) a non-encapsulated oil phase comprising a hydrophobic active ingredient;
(ii) solid particles that are insoluble in water; and
(iii) water;
b) adding a core-shell microcapsule slurry to the emulsion of step a), said slurry comprising microcapsules having a polymeric shell and a core comprising an encapsulated oil phase; and
c) drying the emulsion of step b) to obtain a powdered composition;
wherein the powdered composition comprises the encapsulated oil phase and the non-encapsulated oil phase upon drying,
wherein no molecular emulsifier is added at any stage of the process.

2. The process according to claim 1 , wherein step c) consists of spray-drying the mixture.

3. The process according to claim 1 , wherein a hydrophobic active ingredient comprises at least 90% by weight, relative to the total weight of the hydrophobic active ingredient, of compounds having a log P of at least 1.

4. The process according to claim 1 , wherein the polymeric shell of the core-shell microcapsule slurry is made of a material selected from the group consisting of polyurea, polyurethane, polyamide, polyacrylate, polysiloxane, polycarbonate, polysulfonamide, urea formaldehyde, melamine formaldehyde resin, melamine formaldehyde resin cross-linked with polyisocyanate or aromatic polyols, melamine urea resin, melamine glyoxal resin, gelatin/gum arabic shell wall and mixtures thereof.

5. The process according to claim 1 , wherein a weight ratio between the encapsulated oil phase and the non-encapsulated oil phase is between 1/20 and 1/2.

6. The process according to claim 1 , wherein the water-soluble polymer is chosen in the group consisting of maltodextrin, inulin, corn syrup, dextrin, and mixtures thereof.

7. The process according to claim 1 , wherein the solid particles have an average diameter of at most 10 μm.

8. The process according to claim 1 , wherein the solid particles are selected from the group consisting of:
silicon oxides;
metal oxides, hydroxides, salts of inorganic or organic acids and their mixtures;
silver nanoparticles;
magnesium and aluminium silicates;
latexes;
dietary fibers;
cells or fragments thereof;
humic acid;
enteric polymers; and
crystals of fats or fatty acids.

9. The process according to claim 1 , wherein the solid particles are silicon oxides, silicates or metal oxides.

10. A powdered composition comprising granules made of:
a water soluble polymer matrix,
an oil phase comprising a hydrophobic active ingredient, said oil phase being dispersed in the matrix, wherein one part of the oil phase is freely dispersed within the matrix and wherein one part of the oil phase is encapsulated in core-shell microcapsules, and
solid particles that are insoluble in water;
said powder being obtained by a process comprising the steps of:
a) adding a solution of a water-soluble polymer to a Pickering emulsion, wherein the Pickering emulsion comprises
(i) a non-encapsulated oil phase comprising a hydrophobic active ingredient;
(ii) solid particles that are insoluble in water; and
(iii) water;

b) adding a core-shell microcapsule slurry to the emulsion of step a), said slurry comprising microcapsules having a polymeric shell and a core comprising encapsulated oil; and
c) drying the emulsion of step b) to obtain a powdered composition,
wherein no molecular emulsifier is added at any stage of the process.

11. A consumer product comprising the powdered composition according to claim 10 .

12. The consumer product according to claim 11 , wherein said product is a flavoured or fragranced product.

13. The consumer product according to claim 11 in the form of a powder detergent or an antiperspirant or deodorant composition.

14. The process according to claim 1 , wherein the hydrophobic active ingredient is a perfume or a flavour.

15. The process according to claim 5 , wherein the weight ratio between the encapsulated oil phase and the non-encapsulated oil phase is between 1/10 and 1/3.

16. The powdered composition comprising according to claim 10 , wherein the oil phase of the granules comprises a perfume or a flavor.

17. The powdered composition comprising according to claim 10 , wherein the non-encapsulated oil phase of the Pickering emulsion comprises a perfume or a flavor.

18. The powdered composition comprising according to claim 10 , wherein the oil phase of the granules comprises a perfume or a flavor and the non-encapsulated oil phase of the Pickering emulsion comprises a perfume or a flavor.

19. The process according to claim 1 , wherein a total amount of the encapsulated oil phase and the non-encapsulated oil phase lost during the drying step c) is below 25% by weight.

20. The process according to claim 1 , wherein a total amount of the encapsulated oil phase and the non-encapsulated oil phase present in the obtained powdered composition is from 10% to 50%, by weight of the powdered composition.

Assignees

• Firmenich & Cie

Inventors

• Bouquerand Pierre-Etienne
• Beaussoubre Pascal
• Fieber Wolfgang
• Meyer François

Classifications

• A61K8/732

  Starch; Amylose; Amylopectin; Derivatives thereof · CPC title

• A23L27/72

  Encapsulation · CPC title

• A61K8/0229

  Sticks · CPC title

• A61Q13/00

  Formulations or additives for perfume preparations (essential oils or perfumes per se C11B9/00) · CPC title

• C11D3/00

  Other compounding ingredients of detergent compositions covered in group C11D1/00 · CPC title