System and methods for treatment of wounds with negative pressure and peroxy pyruvic acid

Patent metadata

Field	Value
Publication number	US-11259528-B2
Application number	US-201615392232-A
Country	US
Kind code	B2
Filing date	Dec 28, 2016
Priority date	Dec 29, 2015
Publication date	Mar 1, 2022
Grant date	Mar 1, 2022

Abstract

In one example embodiment, a system for treating a tissue site is disclosed comprising a dressing adapted to contact the tissue site and provide a fluid seal between a therapeutic environment and a local external environment, and a solution source fluidly coupled to the dressing and adapted to deliver an antimicrobial solution comprising a peroxy α-keto carboxylic acid, such as peroxy pyruvic acid, to the tissue interface. The system may further comprise a negative-pressure source fluidly coupled to the dressing and adapted to provide negative pressure to the therapeutic environment after delivery of the antimicrobial fluid to the therapeutic environment. In another example embodiment, a method for treating a tissue site is disclosed comprising positioning a tissue interface to contact the tissue site, covering the tissue interface and the tissue site with a drape to provide a fluid seal between the therapeutic environment and the local external environment, and delivering an antimicrobial solution comprising peroxy α-keto carboxylic acid to the therapeutic environment before providing negative pressure to the therapeutic environment.

First claim

What is claimed is:

1. A system for treating a tissue site, comprising:
a dressing including a manifold adapted to contact the tissue site and a cover adapted to provide a fluid seal between a therapeutic environment including the manifold proximate one side of the cover and a local external environment on the other side of the cover;
a fluid-delivery interface fluidly coupled to the dressing, wherein the fluid-delivery interface comprises an inlet pad;
a positive-pressure source operable to fluidly couple to a solution source and adapted to actuate a solution source for delivering an antimicrobial solution comprising peroxy pyruvic acid to the manifold; and
a negative-pressure source fluidly coupled to the dressing and adapted to provide negative pressure to the therapeutic environment after delivery of the antimicrobial solution to the manifold;
wherein the manifold comprises a porous foam material having interconnected pores for distributing the antimicrobial solution to the therapeutic environment; and wherein the pores have a size of 400 to 600 microns; and
wherein the antimicrobial solution comprises the peroxy pyruvic acid at a concentration of about 2% to about 0.005%.

2. The system according to claim 1 , wherein the negative-pressure source is further adapted to provide negative pressure to the therapeutic environment before or during delivery of the antimicrobial solution to the manifold.

3. The system according to claim 1 , further comprising a processor operatively coupled to the negative-pressure source to provide a target pressure to the therapeutic environment in a pressure control mode.

4. The system according to claim 1 , further comprising a processor operatively coupled to the negative-pressure source to provide a variable target pressure to the therapeutic environment in a dynamic pressure mode.

5. The system according to claim 1 , further comprising a processor operatively coupled to the positive-pressure source to provide the antimicrobial solution to the manifold for one or both of a predetermined dosage or a predetermined time.

6. The system according to claim 1 , further comprising a processor operatively coupled to the negative-pressure source and the positive-pressure source to provide negative pressure to the therapeutic environment prior to, during, or after providing the antimicrobial solution to the manifold.

7. The system according to claim 1 , wherein the solution source is a container filled with the antimicrobial solution.

8. A method for treating a tissue site, comprising:
positioning a manifold to contact the tissue site;
covering the manifold and the tissue site with a drape to provide a fluid seal between a therapeutic environment including the manifold on one side of the drape and a local external environment on the other side of the drape;
fluidly coupling a fluid-delivery interface to the dressing, wherein the fluid-delivery interface comprises an inlet pad;
delivering an antimicrobial solution comprising peroxy pyruvic acid from a solution source fluidly coupled to the manifold; and
providing negative pressure to the therapeutic environment after delivery of the antimicrobial solution to the manifold from a negative-pressure source fluidly coupled to the therapeutic environment;
wherein the manifold comprises a porous foam material having interconnected pores for distributing the antimicrobial solution to the therapeutic environment; and wherein the pores have a size of 400 to 600 microns; and
wherein the antimicrobial solution comprises the peroxy pyruvic acid at a concentration of about 2% to about 0.005%.

9. The method according to claim 8 , further providing negative pressure to the therapeutic environment before or during delivery of the antimicrobial solution.

10. The method according to claim 8 , further providing the antimicrobial solution to the manifold in a predetermined dosage.

11. The method according to claim 8 , further providing the antimicrobial solution to the manifold for a predetermined time.

12. The method according to claim 8 , wherein the delivering of the antimicrobial solution comprises an intermittent flow of fluid soaking the manifold for about one second to about thirty minutes.

13. The method according to claim 8 , wherein the providing the negative pressure and the providing the antimicrobial solution are sequentially repeated two or more times.

14. A dressing for treating a tissue site, comprising:
a porous foam material having interconnected pores forming passageways for distributing negative pressure to the tissue site and adapted to contact the tissue site;
a cover adapted to provide a fluid seal between a therapeutic environment including the porous foam material proximate one side of the cover and a local external environment on the other side of the cover; and
an antimicrobial solution comprising a peroxy pyruvic acid at a concentration of about 2% to about 0.005% permeating at least a portion of the porous foam material;
wherein the porous foam material has a pore size of 400 to 600 microns and operable to deliver both negative pressure and the antimicrobial solution to the therapeutic environment.

Assignees

• Kci Licensing Inc

Inventors

• Ingram Shannon C
• Carroll Christopher A

Classifications

• A21B3/07 Primary

  Charging or discharging ovens (A21B3/18 takes precedence) · CPC title

• A01N37/16 Primary

  containing the group [IMAGE cpc-sch-A01N-0934.gif]; Thio analogues thereof · CPC title

• A61M1/92

  with liquid supply means · CPC title

• A61M1/96

  Suction control thereof · CPC title

• A61M1/915

  Constructional details of the pressure distribution manifold · CPC title