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US-2015369800-A1 · Dec 24, 2015 · US
Polymer-nanostructure composition for selective molecular recognition
US11255848B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11255848-B2 |
| Application number | US-201715606525-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 26, 2017 |
| Priority date | Apr 19, 2010 |
| Publication date | Feb 22, 2022 |
| Grant date | Feb 22, 2022 |
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Abstract
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A composition can include a complex, where the complex includes a photoluminescent nanostructure and a polymer free from selective binding to an analyte, the polymer adsorbed on the photoluminescent nanostructure, and a selective binding site associated with the complex.
First claim
Opening claim text (preview).
What is claimed is: 1. A composition, comprising: a polymer-nanostructure complex including: a photoluminescent nanostructure wherein the nanostructure is a single-walled carbon nanotube; and a polymer including 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(lauroyl), the polymer adsorbed on the nanostructure via non-covalent interactions and the polymer being free from selective binding to an analyte in the absence of being adsorbed on the nanostructure such that the polymer adsorbed on the nanostructure forms a selective binding site that recognizes the analyte, the polymer-nanostructure complex structure as a binding partner for the analyte, which results in a detectable change in photoluminescence. 2. The composition of claim 1 , wherein the polymer further includes polyvinylpyrrolidone, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block co-polymer, a poly(ethylene oxide), poly(N-isopropyl acrylamide), polyethyleneimine, polyacrylamide, polyvinyl alcohol or collagen. 3. The composition of claim 1 , wherein the polymer further includes a dye conjugate or a branched polymer. 4. The composition of claim 1 , wherein the analyte is a monosaccharide, a polysaccharide, an amino acid, a nucleotide, an oligonucleotide, a lipid, a polylipid, a steroid, a peptide, a protein, riboflavin, or nitric oxide. 5. The composition of claim 1 , wherein the analyte is 17-a-estradiol, 2,4-dinitrophenol, acetylcholine chloride, a-tocopherol, adenosine, adenosine-5′-triphosphate, cyclic adenosine monophosphate, creatinine, cytidine, D-aspartic acid, D-fructose, D-galactose, D-glucose, D-mannose, dopamine, glycine, guanosine, histamine, L-ascorbic acid, L-citrulline, L-histidine, L-thyroxine, melatonin, NADH, quinine, salicylic acid, serotonin, sodium azide, sodium pyruvate, sucrose, thymidine, tryptophan, tyramin or urea.
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Classifications
- G01N33/542Primary
with steric inhibition or signal modification, e.g. fluorescent quenching · CPC title
Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title
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- What does patent US11255848B2 cover?
- A composition can include a complex, where the complex includes a photoluminescent nanostructure and a polymer free from selective binding to an analyte, the polymer adsorbed on the photoluminescent nanostructure, and a selective binding site associated with the complex.
- Who is the assignee on this patent?
- Massachusetts Inst Technology
- What technology area does this patent fall under?
- Primary CPC classification G01N33/542. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Feb 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).