Integrated dielectrophoretic and surface plasmonic apparatus and methods for improvement in the detection of biological molecules
US-2019064139-A1 · Feb 28, 2019 · US
Interdigitated electrodes for in vitro analysis of cells
US11255806B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11255806-B2 |
| Application number | US-201816166836-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 22, 2018 |
| Priority date | Oct 20, 2017 |
| Publication date | Feb 22, 2022 |
| Grant date | Feb 22, 2022 |
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Abstract
Official abstract text for this publication.
Described are interdigitated electrodes, which may optionally be plasmonic, useful for in vitro biosensing applications. Such devices may significantly reduce undesired background noise by separating the excitation source (light) from the detection signal (current), and thereby, leading to higher sensitivity for bioanalysis compared with conventional interdigitated electrodes. Also described are methods of making such interdigitated electrodes, which allow a substrate, which may optionally be plasmonic, to be tuned not only to maximize the targeted interaction of the cells with the nanoscale geometry, but also for the excitation wavelength to minimize biological sample interference.
First claim
Opening claim text (preview).
What is claimed is: 1. An interdigitated electrode device comprising interdigitated electrodes disposed on a nanostructured polymer layer, wherein the nanostructured polymer layer comprises a plurality of nanoholes, and wherein the interdigitated electrode device is plasmonic; and a culture well that is disposed on the interdigitated electrodes, wherein the culture well is coated with a biocompatible polymer. 2. The interdigitated electrode device of claim 1 , wherein the interdigitated electrodes comprise a material selected from a noble metal, a semimetal, and combinations thereof. 3. The interdigitated electrode device of claim 1 , wherein the nanostructured polymer layer comprises polyacrylonitrile (PAN). 4. The interdigitated electrode device of claim 1 , wherein the plurality of nanoholes have an average diameter of from about 20 to about 300 nm. 5. The interdigitated electrode device of claim 1 , wherein each of the plurality of nanoholes extends through a thickness of the nanostructured polymer layer. 6. The interdigitated electrode device of claim 5 , wherein the thickness of the nanostructured polymer layer is from about 1 to about 20 μm. 7. The interdigitated electrode device of claim 1 , wherein the plurality of nanoholes have a pitch of from about 50 to about 500 nm. 8. The interdigitated electrode device of claim 1 , further comprising a transparent glass substrate, wherein the nanostructured polymer layer is disposed on the transparent glass substrate. 9. The interdigitated electrode device of claim 1 , wherein the interdigitated electrodes have a pitch of 1 mm.
Assignees
Inventors
Classifications
- C12M41/46Primary
of cellular or enzymatic activity or functionality, e.g. cell viability · CPC title
Measure of electrical or magnetical factor · CPC title
Electrodes · CPC title
Dielectric impedance spectroscopy (electrochemical impedance spectroscopy for measuring corrosion G01N17/02) · CPC title
Well or multiwell plates (C12M25/04 takes precedence) · CPC title
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- What does patent US11255806B2 cover?
- Described are interdigitated electrodes, which may optionally be plasmonic, useful for in vitro biosensing applications. Such devices may significantly reduce undesired background noise by separating the excitation source (light) from the detection signal (current), and thereby, leading to higher sensitivity for bioanalysis compared with conventional interdigitated electrodes. Also described ar…
- Who is the assignee on this patent?
- Univ Central Florida Res Found Inc
- What technology area does this patent fall under?
- Primary CPC classification C12M41/46. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 22 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).