Clot retrieval system for removing occlusive clot from a blood vessel

Patent metadata

Field	Value
Publication number	US-11253278-B2
Application number	US-201816021505-A
Country	US
Kind code	B2
Filing date	Jun 28, 2018
Priority date	Nov 26, 2014
Publication date	Feb 22, 2022
Grant date	Feb 22, 2022

Abstract

A clot removal device for removing clot from a body vessel comprising an expandable structure and an elongate member. The elongate member can have a proximal end and a distal end, the elongate member being connected to the expandable structure at its distal end. The expandable structure can have a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration. At least a portion of the expandable structure can be configured to engage clot in the expanded deployed configuration and to pinch clot on movement from the deployed configuration to the clot pinching configuration.

First claim

The invention claimed is:

1. A clot retrieval device for removing an occlusive clot from a blood vessel, comprising:
an expandable structure comprising a network of interconnected struts configured to engage with the clot and comprising a constrained delivery configuration and an expanded clot engaging deployed configuration, the network being configured in the expanded clot engaging deployed configuration so at least a portion of the interconnected struts interpenetrates the clot, the expandable structure comprising a distal section comprising an open distal end and a proximal pinch section;
a clot engaging element comprising a constrained delivery configuration and an expanded deployed configuration, the clot engaging element being configured to exert an outward radial force when deployed within a lumen whose inner diameter is lower than that of the expanded deployed configuration, the outward radial force varying in a generally sinusoidal pattern along the length of the clot engaging element, the generally sinusoidal pattern comprising a wave pattern that decreases along a length of the device, the amplitude being higher at a proximal end and lower at a distal end of the device;
an elongate member comprising a proximal end and a distal end, the distal end being connected to a proximal end of the expandable structure; and
a proximal joint between the elongate member and the expandable structure, the proximal joint comprising a step at the distal end of the elongate member.

2. The device of claim 1 , wherein the clot engaging element comprises a plurality of adjacent segments, and the outward radial force of at least two adjacent segments differ from each other.

3. The device of claim 1 , wherein the proximal joint comprises a locking collar for engagement with the elongate member and the proximal end of the expandable structure.

4. The device of claim 1 , wherein the distal end of the expandable structure comprises a recess configured for engagement with the step at the distal end of the elongate member.

5. The device of claim 1 , wherein the distal end of the expandable structure comprises a slot configured for engagement with the step at the distal end of the elongate member.

6. A method of treating a patient with a fibrin rich clot, the method comprising:
delivering a removal catheter and a clot retrieval device to a site of the occlusion in a blood vessel, the clot retrieval device comprising:
an expandable structure comprising a network of interconnected struts configured to engage with the clot and comprising a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration, the network being configured in the expanded clot engaging deployed configuration so at least a portion of the network interpenetrates the clot,
the expandable structure comprising:
a distal section comprising an open distal end; and
a proximal pinch section comprising a diameter less than a diameter of the distal section, the proximal pinch section configured to pinch the clot on movement from the expanded clot engaging deployed configuration to the at least partially constrained clot pinching configuration,
the proximal pinch section being further configured such that when the network of interconnected struts is collapsed while in a state of interpenetration with the clot that at least a portion of the proximal pinch section pinches at least a portion of the clot; and
an elongate member comprising a proximal end and a distal end connected to a proximal end of the expandable structure;

deploying the expandable structure into contact with at least a portion of the clot;
advancing the removal catheter along the elongate member while maintaining a position of the elongate member;
engaging a collar of the removal catheter with the expandable structure and effecting the proximal pinch section so as to pinch at least a portion of the clot; and
withdrawing the removal catheter and the clot retrieval device from the vessel while maintaining engagement between the collar and the expandable element.

7. The method of claim 6 , wherein the distal section further comprises a distal barrel section flared outwardly to form a barrel shape with the open distal end, and
wherein the network of interconnected struts comprises at least a plurality of proximally facing struts and a plurality of distally facing struts,
a length of at least some of the proximally facing struts being larger than a length of at least some of the distally facing struts thereby varying an outward radial force of the device in the expanded clot engaging deployed configuration.

Assignees

• Neuravi Ltd

Inventors

• Casey Brendan
• Vale David
• Holian Maeve
• Hardiman David
• O'Connor Grainne

Classifications

• A61B17/22031 Primary

  Gripping instruments, e.g. forceps, for removing or smashing calculi (A61B17/221 takes precedence) · CPC title

• A61B2090/3966

  Radiopaque markers visible in an X-ray image · CPC title

• A61B17/221 Primary

  Gripping devices in the form of loops or baskets {for gripping calculi or similar types of obstructions (surgical snare instruments A61B17/32056)} · CPC title

• A61B2017/22067

  Blocking; Occlusion (A61B2017/22054 takes precedence) · CPC title

• A61B2017/00526

  Methods of manufacturing · CPC title