Devices with reduced microfluidic volume between sensors and sweat glands

Patent metadata

Field	Value
Publication number	US-11253190-B2
Application number	US-201716310551-A
Country	US
Kind code	B2
Filing date	Jul 3, 2017
Priority date	Jul 1, 2016
Publication date	Feb 22, 2022
Grant date	Feb 22, 2022

Abstract

A sweat sampling and sensing device for sensing sweat on skin includes an analyte-specific sensor for sensing a first analyte in sweat; a sweat collector placed on or adjacent to skin with a plurality of pores or pathways for entry of sweat from skin into said sweat collector, said sweat collector at least partly defining a sweat volume between said analyte-specific sensor and the skin; and a pressure element capable of holding said sweat collector against the skin with a pressure and reducing the sweat volume between said sweat collector and the skin.

First claim

What is claimed is:

1. A sweat sampling and sensing device for sensing sweat on skin comprising:
an analyte-specific sensor for sensing a first analyte in sweat;
a sweat collector adapted to be placed on or adjacent to the skin with one or more pores or pathways for entry of sweat from the skin into said sweat collector, said sweat collector at least partly defining a sweat volume between said analyte-specific sensor and the skin; and
a pressure element capable of holding said sweat collector against the skin with a pressure and reducing the sweat volume between said sweat collector and the skin;
wherein the pressure element comprises an adhesive that has a contact area with skin that is at least 3× greater than a contact area of the sweat collector with skin, and the pressure is in a range of at least 60 N/m 2 and less than 40,000 N/m 2 .

2. The device of claim 1 , wherein said pressure element comprises at least one of: an adhesive; a memory foam; a sponge; a mechanical clamp; a spring; a fluid filled bag; a gel; a hydrogel; a strap; a plastic housing; a vacuum providing component; or a negative fluid pressure providing component.

3. The device of claim 1 , wherein said pressure element comprises at least in part an adhesive that has 10× greater contact with skin than contact area of said sweat collector.

4. The device of claim 1 , further comprising a sweat-impermeable non-solid material coating on said sweat collector.

5. The device of claim 4 , wherein said sweat-impermeable non-solid material is an oil.

6. The device of claim 4 , wherein said sweat-impermeable non-solid material is a gel.

7. The device of claim 4 , wherein said sweat-impermeable non-solid material is an adhesive.

8. The device of claim 4 , wherein said sweat-impermeable non-solid material is a paste.

9. The device of claim 1 , wherein said one or more pores or pathways are incompressible.

10. The device of claim 1 , further comprising an oleoscopic material.

11. The device of claim 1 , further comprising a vacuum providing component and a vacuum sealing material adapted to be placed on skin.

12. The device of claim 1 , further comprising a negative fluid pressure providing component and a vacuum sealing material adapted to be placed on skin.

13. The device of claim 1 , wherein the pressure element is configured to hold the device against the skin with a substantially constant pressure, wherein the pressure element compensates for pressure variabilities due to initial donning variations, and due to motion while the device is in use.

14. The device of claim 13 , wherein the pressure element comprises one of the following: an elastomeric bellows, a flexible suspension collar, or a fabric decoupler.

15. The device of claim 14 , wherein the pressure element comprises the flexible suspension collar, the flexible suspension collar comprising a plurality of sections, at least one of the plurality of sections having a different density than the other sections.

16. The device of claim 14 , wherein the pressure element comprises the flexible suspension collar, the flexible suspension collar comprising a plurality of wires made from a superelastic metal alloy.

17. The device of claim 14 , wherein the pressure element comprises the flexible suspension collar, the flexible suspension collar comprising a plurality of wires made from spring steel.

18. The device of claim 1 , further comprising a flexible seal tracing the sweat collector's path of contact with the skin, where the pressure element is configured to apply sufficient pressure between the seal and the skin to prevent sweat from entering the collection area from outside the seal.

19. The device of claim 1 , wherein said analyte-specific sensor is positioned on an interior surface of the sweat collector.

Assignees

• Univ Cincinnati
• Eccrine Systems Inc

Inventors

• Ortiz Mark S
• Stewart Kyle N
• Roth Robert
• Heikenfeld Jason Charles

Classifications

• A61B5/6831 Primary

  Straps, bands or harnesses · CPC title

• A61B5/6832

  using adhesives (conductive adhesive for bioelectric electrodes A61B5/259) · CPC title

• A61B5/6838

  Clamps or clips · CPC title

• A61B5/6833

  Adhesive patches · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title