Radiation treatment planning and delivery for moving targets in the heart

Patent metadata

Field	Value
Publication number	US-11241590-B2
Application number	US-202017038912-A
Country	US
Kind code	B2
Filing date	Sep 30, 2020
Priority date	Mar 16, 2007
Publication date	Feb 8, 2022
Grant date	Feb 8, 2022

Abstract

Methods and systems are disclosed for radiating a moving object. The method may comprise acquiring a plurality of indicators of the phase of a physiological cycle of a patient and a plurality of images of the patient that include a target. Each image may be taken at a different phase of the physiological cycle and may be registered to the phase at which the image was taken. The method may also include identifying the target in each of the plurality of images, calculating a dose of radiation required to treat the target, calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target, and calculating a position of each of the one or more radiation beams required to achieve the calculated orientation. Each position may be a function of the phase of the physiological cycle to which each of the plurality of images is registered.

First claim

We claim:

1. A method of planning radiating of a moving object, comprising:
acquiring a plurality of indicators of the phase of a physiological cycle of a patient;
acquiring a plurality of images of the patient that include a target, each image taken at a different phase of the physiological cycle and registered to the phase at which the image was taken;
identifying the target in each of the plurality of images;
calculating a dose of radiation required to treat the target;
calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target; and
calculating a position of each of the one or more radiation beams required to achieve the calculated orientation, wherein each of the positions is a function of the phase of the physiological cycle to which each of the plurality of images is registered.

2. The method of claim 1 , wherein the physiological cycle is a heartbeat cycle or a respiratory cycle.

3. The method of claim 2 , wherein the heartbeat cycle is determined by EKG.

4. The method of claim 1 , wherein the physiological cycle is both a heartbeat cycle and a respiratory cycle.

5. The method of claim 1 , wherein calculating the number, orientation, and dwell time of one or more radiation beams is a function comprising the types of tissue both in and surrounding the target.

6. The method of claim 5 , wherein calculating number, orientation, and dwell time of one or more radiation beams is further a function of a maximum radiation dose sustainable by the tissue surrounding the target.

7. The method of claim 1 , further comprising:
calculating a radiation-dose distribution for each of the plurality of images based on the calculated number, orientation, and dwell time of the one or more radiation beams.

8. The method of claim 7 , wherein the radiation-dose distribution is further calculated as a function of the types of tissue both in and surrounding the target.

9. The method of claim 7 , further comprising displaying the radiation-dose distribution on a three-dimensional representation of the acquired images.

10. The method of claim 9 , wherein the display of the radiation-dose distribution on a three-dimensional representation of the acquired images is achieved by at least one of: volume rendering; maximum intensity projection; minimum intensity projection; X-ray projection; haptic feedback; virtual fly-through; stereoscopic 3D rendering; virtual reality; and multi-planar, oblique and curved reconstructions.

11. The method of claim 1 , wherein each of the images is one of a CT scan, MRI, PET scan, or ultrasound.

12. The method of claim 1 , wherein identifying the target further comprises identifying a margin that includes a targeted tissue based on a defined likelihood that targeted tissue will be in target.

13. A non-transitory computer-readable storage medium comprising a set of computer executable instructions configured to cause a computer process to carry out the steps of:
acquiring a plurality of indicators of the phase of a physiological cycle of a patient;
acquiring a plurality of images of the patient that include a target, each image taken at a different phase of the physiological cycle and registered to the phase at which the image was taken;
identifying the target in each of the plurality of images;
calculating a dose of radiation required to treat the target;
calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target; and
calculating a position of each of the one or more radiation beams required to achieve the calculated orientation, wherein each of the positions is a function of the phase of the physiological cycle to which each of the plurality of images is registered.

Assignees

• Varian Med Sys Inc

Inventors

• Sumanaweera Thilaka
• Maguire Patrick
• Gardner Edward

Classifications

• A61B5/318

  Heart-related electrical modalities, e.g. electrocardiography [ECG] · CPC title

• A61N5/1067

  in real time, i.e. during treatment · CPC title

• A61B5/0022

  Monitoring a patient using a global network, e.g. telephone networks, internet · CPC title

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• A61N2005/1061

  using an x-ray imaging system having a separate imaging source · CPC title