Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
US-2018022710-A1 · Jan 25, 2018 · US
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
US11241430B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11241430-B2 |
| Application number | US-201916679592-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 11, 2019 |
| Priority date | Jan 30, 2014 |
| Publication date | Feb 8, 2022 |
| Grant date | Feb 8, 2022 |
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- Title
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- Abstract
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Abstract
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Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of purifying a compound of formula (iv), the method comprising 1) dissolving the compound of formula (iv) in a first solvent at a first temperature; 2) adding a second solvent into the resulting solution; 3) cooling the solution to a second temperature; and 4) collecting a solid, wherein R 1 is substituted or unsubstituted C 1-8 alkyl, or substituted or unsubstituted cycloalkyl; and R 2 is substituted or unsubstituted C 1-8 alkyl, or substituted or unsubstituted cycloalkyl. 2. The method of claim 1 , wherein R 2 is 3. The method of claim 1 , wherein R 1 is 4. The method of claim 1 , wherein the first solvent is ethanol or a mixture of 2-propanol and water. 5. The method of claim 1 , wherein the first temperature is about 60° C. or about 70° C. 6. The method of claim 1 , wherein the second solvent is water. 7. The method of claim 1 , wherein the second temperature is about 0° C. or about 25° C. 8. The method of claim 1 , wherein the first solvent is a mixture of 2-propanol and water. 9. The method of claim 8 , wherein the volume ratio between 2-propanol and water in the mixture is about 3:1. 10. The method of claim 1 , wherein the first temperature is about 70° C. 11. The method of claim 1 , wherein the second temperature is about 0° C.
Assignees
Inventors
Classifications
- C07D239/48Primary
Two nitrogen atoms · CPC title
One nitrogen atom (nitro radicals C07D239/30) · CPC title
- A61K31/505Primary
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim · CPC title
- C07D239/28Primary
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms · CPC title
Crystalline forms, e.g. polymorphs · CPC title
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- What does patent US11241430B2 cover?
- Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
- Who is the assignee on this patent?
- Signal Pharm Llc
- What technology area does this patent fall under?
- Primary CPC classification C07D239/48. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).