Antiproliferative compounds and methods of use thereof

Patent metadata

Field	Value
Publication number	US-11241423-B2
Application number	US-201916436819-A
Country	US
Kind code	B2
Filing date	Jun 10, 2019
Priority date	Jul 11, 2014
Publication date	Feb 8, 2022
Grant date	Feb 8, 2022

Abstract

Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

First claim

What is claimed is:

1. A method of treating leukemia in a mammal comprising administering to the mammal a therapeutically effective amount of (2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide), or a pharmaceutically acceptable salt, thereof.

2. The method of claim 1 , wherein the leukemia is chronic lymphocytic leukemia, chronic myelocytic leukemia, acute lymphoblastic leukemia or acute myeloid leukemia.

3. The method of claim 2 , wherein the leukemia is an acute myeloid leukemia.

4. The method of claim 1 , wherein the leukemia is relapsed, refractory or resistant to conventional therapy.

5. The method of claim 1 , further comprising administering a therapeutically effective amount of another second active agent or a support care therapy.

6. The method of claim 5 , wherein the other second active agent is a therapeutic antibody that specifically binds to a cancer antigen, hematopoietic growth factor, cytokine, anti-cancer agent, antibiotic, cox-2 inhibitor, immunomodulatory agent, immunosuppressive agent, corticosteroid or a pharmacologically active mutant or derivative thereof.

Assignees

• Celgene Corp

Inventors

• Cathers Brian E
• Hansen Joshua
• Khalil Ehab M
• Lopez-Girona Antonia
• Macbeth Kyle
• Man Hon-Wah
• Muller George W
• Pourdehnad Michael
• Raheja Raj

Classifications

• A61K31/4545

  containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine · CPC title

• C07D401/04 Primary

  directly linked by a ring-member-to-ring-member bond · CPC title

• A61K31/506

  not condensed and containing further heterocyclic rings · CPC title

• A61K31/501

  not condensed and containing further heterocyclic rings · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title