N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the κ opioid receptor

Patent metadata

Field	Value
Publication number	US-11241415-B2
Application number	US-201916412096-A
Country	US
Kind code	B2
Filing date	May 14, 2019
Priority date	Dec 23, 2014
Publication date	Feb 8, 2022
Grant date	Feb 8, 2022

Abstract

Compounds and pharmaceutically acceptable salts and solvates thereof are described. The compounds relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology and organic chemistry.

First claim

What is claimed is:

1. A compound having the formula:

wherein:
R 1 is selected from H or —OCH 2 CH 2 OH;
R 2 is selected from —NH—(CH 2 CH 2 O) a —Y or —NH—(CH 2 CH 2 O) a —Y;
Y is selected from —CH 3 , —CF 3 , or —OH;
a is selected from 0, 1, 2, 3 and 4;
or pharmaceutically acceptable salts and solvates thereof.

2. The compound of claim 1 having the formula selected from:

3. A pharmaceutical composition comprising the compound of claim 1 and at least one pharmaceutically acceptable excipient.

4. A composition of matter comprising the compound of claim 1 , wherein the compound is present in a dosage form.

5. A method of treating pain comprising administering the compound of claim 1 to a patient in need thereof.

Assignees

• Nektar Therapeutics

Inventors

• Duarte Franco J
• Anand Neel K
• Zhang Wen
• Sharma Pankaj
• Singh Devendrapratap

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• C07D207/04

  having no double bonds between ring members or between ring members and non-ring members · CPC title

• C07D231/18

  One oxygen or sulfur atom · CPC title

• C07D207/14

  Nitrogen atoms not forming part of a nitro radical · CPC title

• C07D295/13

  to an acyclic saturated chain · CPC title