System, method and computer simulation environment for in silico trials in pre-diabetes and type 2 diabetes

Patent metadata

Field	Value
Publication number	US-11238990-B2
Application number	US-201013380839-A
Country	US
Kind code	B2
Filing date	Jun 25, 2010
Priority date	Jun 26, 2009
Publication date	Feb 1, 2022
Grant date	Feb 1, 2022

Abstract

An electronic system is provided that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, wherein the system includes a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic module that models endogenous glucose production (EGP(t)), or meal glucose rate of appearance (Ra(t>>, or glucose utilization (U(t)), or renal excretion of glucose (B(t)), a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic module that models insulin secretion (S(t)), an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters, and a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose insulin metabolic system of a virtual subject by inputting the plurality of metabolic parameter values.

First claim

What is claimed is:

1. An electronic system that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, comprising:
a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including:
an electronic module that models endogenous glucose production (EGP(t)) of a T2DM or prediabetic subject,
an electronic module that models meal glucose rate of appearance (Ra(t)) of a T2DM or prediabetic subject,
an electronic module that models glucose utilization (U(t)) of a T2DM or prediabetic subject,
an electronic module that models renal excretion of glucose (E(t)) of a T2DM or prediabetic subject;

a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including:
an electronic module that models insulin secretion (S(t)) of a T2DM or prediabetic subject;
an electronic database containing a population of virtual T2DM or prediabetic subjects representative of the T2DM and prediabetic population, each virtual subject having a plurality of metabolic parameters with values encompassing a distribution of parameters observed in vivo across the population of T2DM or prediabetic subjects; and
a processor that calculates an effect of variation of at least one metabolic parameter value on the glucose-insulin metabolic system of a virtual T2DM or prediabetic subject by inputting said plurality of metabolic parameter values of said T2DM or prediabetic subject into said glucose concentration and insulin concentration subsystems and varying at least one of said metabolic parameter values to determine its effect on the glucose-insulin metabolic system of said T2DM or prediabetic subject.

2. An electronic system as set forth in claim 1 , wherein said glucose concentration subsystem models T2DM or prediabetic glucose concentration G(t) in accordance with the following equations:

{

G
.

p

⁡

(
t
)

=

EGP
⁡

(
t
)

+

Ra
⁡

(
t
)

-

U
ii

⁡

(
t
)

-

E
⁡

(
t
)

-

G
p

⁡

(
0
)

=

G
pb

k
1

·

G
p

⁡

(
t
)

+

k
2

·

G
t

⁡

(
t
)

G
.

t

⁡

(
t
)

=

-

U
id

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(
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)

+

k
1

·

G
p

⁡

Assignees

• Kovatchev Boris P
• Cobelli Claudio
• Dalla Man Chiara
• Univ Virginia Patent Foundation

Inventors

• Kovatchev Boris P
• Cobelli Claudio
• Dalla Man Chiara

Classifications

• G16H10/60

  for patient-specific data, e.g. for electronic patient records · CPC title

• G16H50/50 Primary

  for simulation or modelling of medical disorders · CPC title

• G06N5/00

  Computing arrangements using knowledge-based models · CPC title

• A61B5/7275

  Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor · CPC title

• A61B5/4842

  Monitoring progression or stage of a disease · CPC title