Modified polypeptide having homoserine acetyltransferase activity and microorganism expressing the same
US-9127257-B2 · Sep 8, 2015 · US
Modified homoserine dehydrogenase and method for producing homoserine or L-amino acid derived from homoserine using the same
US11236374B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11236374-B2 |
| Application number | US-201916483309-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 21, 2019 |
| Priority date | May 28, 2018 |
| Publication date | Feb 1, 2022 |
| Grant date | Feb 1, 2022 |
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Abstract
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The present disclosure relates to modified homoserine dehydrogenase and a method for producing a homoserine-derived L-amino acid using the same.
First claim
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The invention claimed is: 1. A modified homoserine dehydrogenase having at least 95% sequence identity with the polypeptide of SEQ ID NO: 1, wherein said modified homoserine dehydrogenase comprises an isoleucine at the position corresponding to position 285 of the polypeptide of SEQ ID NO: 1, and/or a glutamine at the position corresponding to position 398 of the polypeptide of SEQ ID NO: 1, and wherein the modified homoserine dehydrogenase has homoserine dehydrogenase activity. 2. The modified homoserine dehydrogenase according to claim 1 , wherein said modified homoserine dehydrogenase further comprises a tryptophan at the position corresponding to position 378 of the polypeptide of SEQ ID NO: 1. 3. A microorganism of the genus Corynebacterium , comprising the modified homoserine dehydrogenase of claim 1 . 4. The microorganism according to claim 3 , wherein the microorganism of the genus Corynebacterium is a microorganism of the genus Corynebacterium producing homoserine or a homoserine-derived L-amino acid. 5. The microorganism according to claim 4 , wherein the homoserine-derived L-amino acid is at least one selected from the group consisting of L-threonine, L-isoleucine, O-acetyl homoserine, and L-methionine. 6. The microorganism according to claim 3 , wherein the microorganism of the genus Corynebacterium produces L-alanine. 7. The microorganism according to claim 3 , wherein the microorganism of the genus Corynebacterium is Corynebacterium glutamicum. 8. A method for producing homoserine or a homoserine-derived L-amino acid, comprising: culturing the microorganism of claim 3 in a medium; and recovering homoserine or a homoserine-derived L-amino acid from the microorganism or the medium. 9. The method according to claim 8 , wherein the homoserine-derived L-amino acid is at least one selected from the group consisting of L-threonine, L-isoleucine, O-acetyl homoserine, and L-methionine. 10. A microorganism of the genus Corynebacterium , comprising the modified homoserine dehydrogenase of claim 2 . 11. The microorganism according to claim 10 , wherein the microorganism of the genus Corynebacterium is a microorganism of the genus Corynebacterium producing homoserine or a homoserine-derived L-amino acid. 12. The microorganism according to claim 11 , wherein the homoserine-derived L-amino acid is at least one selected from the group consisting of L-threonine, L-isoleucine, O-acetyl homoserine, and L-methionine. 13. The microorganism according to claim 10 , wherein the microorganism of the genus Corynebacterium produces L-alanine. 14. The microorganism according to claim 10 , wherein the microorganism of the genus Corynebacterium is Corynebacterium glutamicum. 15. A method for producing homoserine or a homoserine-derived L-amino acid, comprising: culturing the microorganism of claim 10 in a medium; and recovering homoserine or a homoserine-derived L-amino acid from the microorganism or the medium. 16. The method according to claim 15 , wherein the homoserine-derived L-amino acid is at least one selected from the group consisting of L-threonine, L-isoleucine, O-acetyl homoserine, and L-methionine.
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- What does patent US11236374B2 cover?
- The present disclosure relates to modified homoserine dehydrogenase and a method for producing a homoserine-derived L-amino acid using the same.
- Who is the assignee on this patent?
- Cj Cheiljedang Corp
- What technology area does this patent fall under?
- Primary CPC classification C12N15/52. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).