Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods

Patent metadata

Field	Value
Publication number	US-11234624-B2
Application number	US-201816185700-A
Country	US
Kind code	B2
Filing date	Nov 9, 2018
Priority date	Jun 8, 2012
Publication date	Feb 1, 2022
Grant date	Feb 1, 2022

Abstract

A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

First claim

What is claimed is:

1. A method of calculating a single, fused sensor glucose value based on respective glucose measurement signals of a plurality of redundant sensing electrodes, comprising:
performing respective electrochemical impedance spectroscopy (EIS) procedures for each of the plurality of redundant sensing electrodes to obtain values of at least one impedance-based parameter for each said sensing electrode;
measuring the electrode current (Isig) for each of the plurality of redundant sensing electrodes;
calibrating each of the measured Isigs to obtain respective calibrated sensor glucose values;
calculating a plurality of reliability indices for each said sensing electrode based on said values of the at least one impedance-based parameter, said plurality of reliability indices including a dip reliability index and a sensitivity-loss reliability index, wherein said sensitivity-loss reliability index is calculated based on trending of said values of the at least one impedance-based parameter; and
calculating said single, fused sensor glucose value based on said plurality of reliability indices and calibrated sensor glucose values of each of the plurality of redundant sensing electrodes.

2. The method of claim 1 , wherein said sensitivity-loss reliability index is calculated based on trending of values of 1 kHz imaginary impedance.

3. The method of claim 2 , wherein said trending of values of 1 kHz imaginary impedance is monitored for a predefined period of time.

4. The method of claim 3 , wherein said predefined period of time is 8 hours.

5. The method of claim 2 , wherein, when a trending of values of 1 kHz imaginary impedance for one of said plurality of redundant sensing electrodes turns negative, said sensitivity-loss reliability index is calculated based on trending of values of 1 kHz imaginary impedance for another one of said plurality of redundant sensing electrodes.

6. The method of claim 1 , wherein said trending is calculated by using a low-pass filter.

7. The method of claim 1 , wherein said plurality of reliability indices include a bound check reliability index and a noise check reliability index.

8. The method of claim 1 , wherein each said respective EIS procedure is performed for a range of frequencies.

9. The method of claim 1 , wherein said plurality of reliability indices include a bound check reliability index and a noise check reliability index, and wherein said bound check reliability index and noise check reliability index are calculated based on values of 1 kHz imaginary impedance and 1 kHz real impedance.

10. The method of claim 9 , wherein calculation of said bound check reliability index and noise check reliability index is further based on values of 0.105 Hz imaginary impedance and 0.105 Hz real impedance.

11. The method of claim 10 , wherein calculation of said bound check reliability index and said noise check reliability index includes determining whether said values of the 0.105 Hz real impedance fall between 2e+4 and 7e+4.

12. The method of claim 10 , wherein calculation of said bound check reliability index and said noise check reliability index includes determining whether said values of the 0.105 Hz imaginary impedance fall between −2e+5 and 0.25e+5.

13. The method of claim 10 , wherein calculation of said bound check reliability index and noise check reliability index is further based on values of Nyquist slope.

14. The method of claim 13 , wherein calculation of said bound check reliability index and said noise check reliability index includes determining whether said values of Nyquist slope fall between 2 and 5.

15. The method of claim 1 , wherein a low-pass filter is applied to said single, fused sensor glucose value.

16. The method of claim 1 , wherein one or more of the at least one impedance-based parameter are substantially glucose-independent.

17. The method of claim 1 , further including calculating, for each of the plurality of electrodes, a weight based on said plurality of reliability indices for each said sensing electrode.

18. The method of claim 17 , wherein said single, fused sensor glucose value is calculated based on the respective weights and calibrated sensor glucose values of each of the plurality of redundant sensing electrodes.

19. The method of claim 1 , wherein, prior to calibrating the measured Isigs, said Isigs are first filtered to remove any EIS-induced spikes therein.

Assignees

• Medtronic Minimed Inc

Inventors

• Yang Ning
• Gautham Raghavendhar
• Liang Bradley C
• Shah Rajiv

Classifications

• G08B21/182

  Level alarms, e.g. alarms responsive to variables exceeding a threshold · CPC title

• A61B5/6886

  Monitoring or controlling distance between sensor and tissue · CPC title

• A61B5/14503

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors (A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence) · CPC title

• A61B5/1495 Primary

  Calibrating or testing of in-vivo probes · CPC title

• A61B5/14865

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title