Deuterated analogs of MK2 inhibitors and uses thereof

Patent metadata

Field	Value
Publication number	US-11230551-B2
Application number	US-201816494711-A
Country	US
Kind code	B2
Filing date	Mar 15, 2018
Priority date	Mar 16, 2017
Publication date	Jan 25, 2022
Grant date	Jan 25, 2022

Abstract

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

First claim

We claim:

1. A compound of Formulae IV, IV′, or IV″:

or a pharmaceutically acceptable salt thereof, whererin:
each of R 7 , R 7′ , R 8 , R 8′ , R 8″ , and R 9 is independently selected from hydrogen or deuterium;
provided that at least one of R 7 , R 7′ , R 8 , R 8′ , R 8″ , and R 9 is deuterium.

2. The compound according to claim 1 , wherein the compound is selected from:

Formula
Formula
Formula

IV
IV′
IV″
R 7
R 7′
R 8
R 8′
R 8″
R 9

IV-1
IV′-1
IV″-1
H
H
D
H
H
H

IV-2
IV′-2
IV″-2
H
H
H
D
H
H

IV-3
IV′-3
IV″-3
H
H
H
H
D
H

IV-4
IV′-4
IV″-4
H
H
D
D
H
H

IV-5
IV′-5
IV″-5
H
H
D
H
D
H

IV-6
IV′-6
IV″-6
H
H
H
D
D
H

IV-7
IV′-7
IV″-7
H
H
D
D
D
H

IV-8
IV′-8
IV″-8
H
D
H
H
H
H

IV-9
IV′-9
IV″-9
H
D
D
H
H
H

IV-10
IV′-10
IV″-10
H
D
H
D
H
H

IV-11
IV′-11
IV″-11
H
D
H
H
D
H

IV-12
IV′-12
IV″-12
H
D
D
D
H
H

IV-13
IV′-13
IV″-13
H
D
D
H
D
H

IV-14
IV′-14
IV″-14
H
D
H
D
D
H

IV-15
IV′-15
IV″-15
H
D
D
D
D
H

IV-16
IV′-16
IV″-16
D
H
H
H
H
H

IV-17
IV′-17
IV″-17
D
H
D
H
H
H

IV-18
IV′-18
IV″-18
D
H
H
D
H
H

IV-19
IV′-19
IV″-19
D
H
H
H
D
H

IV-20
IV′-20
IV″-20
D
H
D
D
H
H

IV-21
IV′-21
IV″-21
D
H
D
H
D
H

IV-22
IV′-22
IV″-22
D
H
H
D
D
H

IV-23
IV′-23
IV″-23
D
H
D
D
D
H

IV-24
IV′-24
IV″-24
D
D
H
H
H
H

IV-25
IV′-25
IV″-25
D
D
D
H
H
H

IV-26
IV′-26
IV″-26
D
D
H
D
H
H

IV-27
IV′-27
IV″-27
D
D
H
H
D
H

IV-28
IV′-28
IV″-28
D
D
D
D
H
H

IV-29
IV′-29
IV″-29
D
D
D
H
D
H

IV-30

Assignees

• Celgene Car Llc

Inventors

• Malona John
• Surapaneni Sekhar S

Classifications

• C07B2200/05

  Isotopically modified compounds, e.g. labelled · CPC title

• C07D495/14 Primary

  Ortho-condensed systems · CPC title

• C12N9/12

  transferring phosphorus containing groups, e.g. kinases (2.7) · CPC title