Systems and methods for vascular occlusion

Patent metadata

Field	Value
Publication number	US-11229440-B2
Application number	US-201615083245-A
Country	US
Kind code	B2
Filing date	Mar 28, 2016
Priority date	Mar 26, 2015
Publication date	Jan 25, 2022
Grant date	Jan 25, 2022

Abstract

Expandable occlusive plugs and methods of using them are disclosed. The devices generally include an expandable framework at least partially covered by a membrane. The occlusive plugs can be used for occlusion of body lumens and/or to limit migration of embolic agents to non-target sites.

First claim

What is claimed is:

1. An occlusive system, comprising:
an expandable device comprising:
an elongate shaft comprising a distal end and a proximal end;
a flexible framework comprising a distal end disposed at the distal end of the elongate shaft, a proximal end, and a length therebetween, the flexible framework moveable between a compressed configuration wherein the proximal end of the flexible framework has a first outer diameter and an uncompressed configuration wherein the proximal end of the flexible framework has a second outer diameter larger than the first outer diameter; and
a membrane at least partially covering the flexible framework;

a pushrod comprising a distal tip configured to deliver the expandable device; and
a dissolvable sleeve disposed along the flexible framework proximate the proximal end of the framework and having a length flexible less than the length of the flexible framework, the dissolvable sleeve further disposed about the distal tip of the pushrod, the dissolvable sleeve configured to constrain the proximal end of the flexible framework in the compressed configuration, and the dissolvable sleeve configured to detachably couple the proximal end of the elongate shaft to the distal tip of the pushrod.

2. The system of claim 1 , wherein the flexible framework is bent radially inward against the elongate shaft in the compressed configuration.

3. The system of claim 1 , wherein the flexible framework is constrained about a surface of the elongate shaft in the compressed configuration.

4. The system of claim 1 , wherein the distal end of the flexible framework is distal to the dissolvable sleeve in the compressed configuration.

5. The system of claim 1 , wherein the first outer diameter is less than an inner diameter of a lumen of a delivery catheter configured to receive the occlusive system with the flexible framework in the compressed configuration.

6. The system of claim 1 , wherein the dissolvable sleeve comprises a dissolvable polymer.

7. The system of claim 1 , wherein the flexible framework comprises a pair of crossed wires with midportions of the wires disposed at the distal end of the elongate shaft.

8. The system of claim 1 , wherein the flexible framework comprises a shape memory material.

9. The system of claim 1 , wherein the flexible framework and membrane define a cone or umbrella shape when in the uncompressed configuration.

10. An occlusive system, comprising:
an expandable device comprising:
an elongate shaft comprising a proximal end and a distal end;
a flexible framework comprising a plurality of wires with wire ends, each wire having a midportion disposed at the distal end of the elongate shaft and the wire ends of each wire bendable towards the proximal end of the elongate shaft, the flexible framework moveable between a compressed configuration wherein the wire ends of the plurality of wires form a first outer diameter and an uncompressed configuration wherein the wire ends of the plurality of wires form a second outer diameter larger than the first outer diameter; and
a membrane covering at least a portion of the flexible framework;

a pushrod comprising a distal tip configured to deliver the expandable device; and
a dissolvable sleeve disposed about the wire ends of the plurality of wires and proximal to the midportion of the plurality of wires, the dissolvable sleeve further disposed about the distal tip of the pushrod, the dissolvable sleeve configured to constrain the flexible framework in the compressed configuration and detachably couple the proximal end of the elongate shaft to the distal tip of the pushrod.

11. The system of claim 10 , wherein the flexible framework is constrained about a portion the elongate shaft in the compressed configuration.

12. The system of claim 10 , wherein the plurality of wires cross each other at the midportion of each wire.

13. The system of claim 10 , wherein the first outer diameter is less than an inner diameter of a lumen of a delivery catheter configured to receive the occlusive system with the flexible framework in the compressed configuration.

14. The system of claim 10 , wherein the dissolvable sleeve comprises a dissolvable polymer.

15. The system of claim 10 , wherein the plurality of wires comprises a pair of crossed wires.

16. The system of claim 10 , wherein the flexible framework and membrane define a cone or umbrella shape when in the uncompressed configuration.

17. A method of delivering an occlusive device, comprising:
inserting an occlusive device into a body lumen via a distal end of a pushrod, the device comprising a flexible framework constrained by a dissolvable sleeve about an elongate member, the dissolvable sleeve having a length less than the length of the flexible framework, the dissolvable sleeve configured to detachably couple a proximal end of the elongate shaft to a distal tip of the pushrod;
delivering the occlusive device into the body lumen by exposing the occlusive device to a body fluid such that the dissolvable sleeve dissolves, allowing the flexible framework to transition from a compressed configuration to an uncompressed configuration and the elongate member to detach from the distal tip of the pushrod.

18. The method of claim 17 , wherein the flexible framework transitions from the compressed configuration to the uncompressed configuration and the elongate member detaches from the distal end of the pushrod, simultaneously.

19. The method of claim 17 , wherein the dissolvable sleeve is distal a proximal end of the flexible framework.

20. The method of claim 17 , wherein the flexible framework comprises a pair of crossed wires with midportions of the wires disposed at a distal end of the elongate member.

Assignees

• Boston Scient Scimed Inc

Inventors

• Squire Robert
• Munsinger Joel
• Larson Derek
• Willard Martin
• Connolly Joseph

Classifications

• A61B2017/4216

  Operations on uterus, e.g. endometrium · CPC title

• A61B17/12022 Primary

  Occluding by internal devices, e.g. balloons or releasable wires (plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20) · CPC title

• A61B2017/1205

  Introduction devices · CPC title

• A61B17/12113

  within an aneurysm · CPC title

• A61B2090/3966

  Radiopaque markers visible in an X-ray image · CPC title