Low-power mass interrogation system and assay for determining vitamin D levels

Patent metadata

Field	Value
Publication number	US-11227754-B2
Application number	US-201916399441-A
Country	US
Kind code	B2
Filing date	Apr 30, 2019
Priority date	Apr 30, 2018
Publication date	Jan 18, 2022
Grant date	Jan 18, 2022

Abstract

A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

First claim

The invention claimed is:

1. A mass spectrometer assembly comprising:
an ionization component for producing sample ions from a sample;
an electrostatic analyzer for receiving the sample ions from the ionization component and producing a preferred set of sample ions, wherein the sample ions pass through a first slit in a first flat plate located between the ionization component and the electrostatic analyzer;
a lens assembly for receiving the preferred set of sample ions from the electrostatic analyzer and focusing the preferred sample set of ions, wherein the preferred set of sample ions pass through a second slit in a second flat plate located between the electrostatic analyzer and the lens assembly;
a magnet assembly located at an output of the lens assembly for creating a permanent magnetic field region beginning at the focal point of the lens assembly for receiving the focused preferred sample set of ions at an entrance thereof and deflecting sample ions within the focused preferred sample set of ions using zero power to a detector, wherein individual sample ions having a range of masses are simultaneously deflected 180 degrees from the focal point and simultaneously detected at different points along the detector in accordance with an individual mass thereof; and
further wherein the detector is located in a same plane as the focal point of the lens assembly entrance to the magnet assembly.

2. The mass spectrometer assembly of claim 1 , wherein the magnet is made of Nd:Fe:B.

3. The mass spectrometer assembly of claim 1 , wherein the detector is charge couple device for detecting charges.

4. The mass spectrometer assembly of claim 1 , further comprising a vacuum chamber housing the ionization component, the electrostatic analyzer, the lens assembly, the magnet assembly and the detector.

5. The mass spectrometer assembly of claim 4 , further comprising at least one pump connected to the vacuum chamber.

6. The mass spectrometer assembly of claim 4 , wherein the vacuum chamber includes first and second chambers to facilitate differential vacuum regions, wherein the ionization component, the electrostatic analyzer and the lens assembly are in a first vacuum region and the magnet assembly and the detector are in a second vacuum region.

7. The mass spectrometer assembly of claim 1 , wherein the ionization component includes thermionic source.

8. The mass spectrometer assembly of claim 1 , wherein the ionization component includes a filament-free and non-radioactive ionization source selected from field emitter array and carbon nanotube (CNT) ionizers.

Assignees

• Leidos Inc

Inventors

• Christian Noah Peter

Classifications

• H01J49/0022 Primary

  Portable spectrometers, e.g. devices comprising independent power supply, constructional details relating to portability (small scale devices per se H01J49/0013 and H01J49/0018) · CPC title

• G01N33/82

  involving vitamins {or their receptors} · CPC title

• H01J49/24

  Vacuum systems, e.g. maintaining desired pressures · CPC title

• H01J49/20

  Magnetic deflection · CPC title

• H01J49/30

  using magnetic analysers {, e.g. Dempster spectrometer} · CPC title