Layered chromatography column cylinder

Patent metadata

Field	Value
Publication number	US-11224827-B2
Application number	US-201716348581-A
Country	US
Kind code	B2
Filing date	Nov 10, 2017
Priority date	Nov 11, 2016
Publication date	Jan 18, 2022
Grant date	Jan 18, 2022

Abstract

Disclosed is a chromatography column cylinder (200) formed from a polymer composite comprising an outer layer (220) and inner layer (210) intended to be in direct contact with the intended contents of the cylinder in a volume (202), wherein the outer layer supports the inner layer, for example when there is negative pressure in the volume (202). In one embodiment, one of said layers is molded directly onto a surface of the other layer such that there is no gap between the two layers. Disclosed also is a method for forming a chromatography column cylinder.

First claim

The invention claimed is:

1. A chromatography column cylinder formed from a polymer composite comprising an outer layer and an inner layer together defining a cylinder volume, the inner layer having an inner surface exposed to the volume, wherein the inner layer is supported by the outer layer, wherein the outer layer is formed from a polymer and is mechanically stronger than the inner layer of the cylinder, wherein the polymer comprises a polymethyl methacrylate or a polymethyl methacrylate modified with additional comonomers, and wherein polymerization of the polymer of the outer layer on the inner layer provides shrinkage of the outer layer to mechanically bond the outer layer to the inner layer.

2. The chromatography column cylinder as claimed in claim 1 , wherein said inner layer support by the outer layer in use is provided by one or more of:
a) directly molding one of said layers onto a surface of the other layer;
b) adhering the inner and outer layers together;
c) complementary formations of the inner and outer layers; or
d) a sealed volume between the inner and outer layers.

3. The chromatography column cylinder as claimed in claim 1 , wherein—the inner layer comprises polypropylene, polyvinyl chloride, high-density polyethylene, polyamide, polyethylene terephthalate, polyether ether ketone, or combinations thereof.

4. The chromatography column cylinder as claimed in claim 1 , wherein the inner layer is formed as a tube, and the outer layer is overlaid onto the inner layer by means of resin molding around the inner layer.

5. The chromatography column cylinder as claimed in claim 1 , wherein the cylinder is a right circular cylinder, or a polygonal cylinder.

6. A chromatography column assembly including a chromatographic column cylinder as claimed in claim 1 .

7. The chromatography column cylinder as claimed in claim 1 , wherein the outer layer consists essentially of a polymethyl methacrylate polymer, and the inner layer consists essentially of a polypropylene polymer.

8. A method for forming a chromatography column cylinder, comprising forming a polymer cylinder as claimed in claim 1 .

9. The method as claimed in claim 8 including any one or more of the steps of:
a) molding one of the layers directly onto the other layer;
b) adhering the inner and outer layers together;
c) forming complementary formations on the inner and outer layers and joining said layers using said complementary formations; and
d) providing a sealed volume between the inner and outer layers, in each case to provide said support.

10. The method as claimed in claim 8 , wherein the material of the inner layer is formed from a relatively more chemically resistant polymer material than the outer layer, and the outer layer is formed from a material which renders the outer layer relatively mechanically stronger than the inner layer.

11. The method as claimed in claim 8 , wherein the inner layer comprises polypropylene, polyvinyl chloride, high-density polyethylene, polyamide, polytetrafluoroethylene, polyethylene terephthalate, polyether ether ketone, or combinations thereof.

12. The method as claimed in claim 8 , wherein the inner layer is formed as a tube and the outer layer is molded directly onto the outer surface of the inner layer.

13. The method as claimed in claim 8 , wherein the outer layer is formed as a tube and the inner layer is molded directly onto the inner wall of the outer layer.

Assignees

• Cytiva Sweden Ab

Inventors

• Lundkvist Mats
• Salomonsson Daniel

Classifications

• G01N30/6052

  body · CPC title

• B32B7/12

  using interposed adhesives or interposed materials with bonding properties · CPC title

• G01N30/6073

  in open tubular form · CPC title

• B01D15/22 Primary

  relating to the construction of the column · CPC title

• B32B2333/12

  Polymers of methacrylic acid esters, e.g. PMMA, i.e. polymethylmethacrylate · CPC title