Modulation of Activity of Neurotrophins
US-2017158766-A1 · Jun 8, 2017 · US
US11220527B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11220527-B2 |
| Application number | US-201716340832-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 11, 2017 |
| Priority date | Oct 11, 2016 |
| Publication date | Jan 11, 2022 |
| Grant date | Jan 11, 2022 |
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Disclosed are new peptides derived from the neurotensin receptor 3 (NTSR3), and to their use, particularly in the treatment of various diseases, especially depression.
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The invention claimed is: 1. A peptide derived from the propeptide (PE) of the neurotensin receptor 3 (NTSR3) selected from the group consisting of: the peptide G/A-PE(22-28) consisting of the amino acid sequence of SEQ ID NO: 7 (AVSWGLR), and the biotinylated peptide G/A-PE(22-28) corresponding to the sequence SEQ ID NO: 7 biotinylated. 2. A medicament comprising the peptide according to claim 1 . 3. The medicament according to claim 2 , wherein the medicament is an antidepressant. 4. A method for treating depression in a subject in need thereof, said method comprising administering to the subject a therapeutically effective amount of the peptide according to claim 1 .
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