Apparatus and method for delivery of antimicrobial during a transdermal sampling and delivery process

Patent metadata

Field	Value
Publication number	US-11219390-B2
Application number	US-201615226475-A
Country	US
Kind code	B2
Filing date	Aug 2, 2016
Priority date	Aug 3, 2015
Publication date	Jan 11, 2022
Grant date	Jan 11, 2022

Abstract

A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.

First claim

The invention claimed is:

1. A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid of a user comprising:
a first substrate having thereon multiple, individually electrically controllable microheating elements including at least a microheater portion with multiple electrodes connected to the microheater portion for accessing the interstitial fluid of the user, the first substrate including multiple first holes therethough which are aligned with the microheater portion of each of the microheating elements; and
a second substrate having a nanofiber material containing at least one antimicrobial applied thereto in the form of multiple individual annulus-shaped nanofiber mats, the second substrate further including multiple second holes therethrough which are aligned with the microheater portion of each of the microheating elements, wherein each of the multiple annulus-shaped nanofiber mats surrounds one of the multiple second holes;
the second substrate further including an adhesive material applied between each of the nanofiber mats to adhere the device to the user's skin;
wherein the nanofiber material, the adhesive material, the second substrate, the first substrate and the microheating elements are arranged in the following order in the device:
first, the nanofiber material and the adhesive material which are configured to contact the user's skin;
second, the second substrate;
third, the first substrate; and
fourth, the microheating elements.

2. The device of claim 1 , wherein one of the at least one antimicrobial is LL-37.

3. The device of claim 1 , wherein the nanofiber mat includes the at least one antimicrobial and at least one additional antimicrobial material therein.

4. The device of claim 3 , wherein the at least two antimicrobial materials are arranged in individual rings comprising the annulus-shaped nanofiber mat.

5. The device of claim 1 , wherein each annulus-shaped nanofiber mats has a width of between 5 to 25 μm.

Assignees

• Univ Georgetown

Inventors

• Paranjape Makarand
• Paranjape Shruti M

Classifications

• A61B5/15134 Primary

  Bladeless capillary blood sampling devices, i.e. devices for perforating the skin in order to obtain a blood sample but not using a blade, needle, canula, or lancet, e.g. by laser perforation, suction or pressurized fluids · CPC title

• A61B5/14514 Primary

  using means for aiding extraction of interstitial fluid, e.g. microneedles or suction · CPC title

• A61B5/150969

  Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing · CPC title

• A61B5/157

  {Devices} characterised by integrated means for measuring characteristics of blood · CPC title

• A61B5/150022

  for capillary blood or interstitial fluid · CPC title