Peptides And Methods For Detecting Peanut Allergies
US-2019359660-A1 · Nov 28, 2019 · US
US11215615B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11215615-B2 |
| Application number | US-201515129979-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 20, 2015 |
| Priority date | Apr 3, 2014 |
| Publication date | Jan 4, 2022 |
| Grant date | Jan 4, 2022 |
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Provided are peptide biomarkers for diagnosis of allergy, monitoring development of clinical tolerance in an allergic individual, and predicting whether an allergic subject is likely to develop clinical or natural tolerance over time. The invention also relates to diagnostic methods and diagnostic kits employing the peptide biomarkers.
Opening claim text (preview).
What is claimed is: 1. A set of allergenic epitope-containing peptides for detection of milk allergy consisting of a plurality of peptides represented by SEQ ID NOs:1-33, wherein the plurality of peptides consists of all 33 peptides of SEQ ID NOs:1-33, a subset of 20-25 peptides, a subset of 15-20 peptides, or a subset of 10-15 peptides, and wherein each peptide is conjugated to a solid support. 2. The set of allergenic epitope-containing peptides of claim 1 , wherein the solid support is a bead, a microtiter plate, or a chromatographic material. 3. The set of allergenic epitope-containing peptides of claim 1 , wherein each peptide is conjugated to a separately identifiable solid support. 4. The set of allergenic epitope-containing peptides of claim 1 , wherein the plurality of peptides consists of all 33 peptides of SEQ ID NOs:1-33. 5. The set of allergenic epitope-containing peptides of claim 1 , wherein the plurality of peptides consists of the subset of 20-25 peptides. 6. The set of allergenic epitope-containing peptides of claim 1 , wherein the plurality of peptides consists of the subset of 15-20. 7. The set of allergenic epitope-containing peptides of claim 1 , wherein the plurality of peptides consists of the subset of 10-15 peptides.
Allergens · CPC title
having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof · CPC title
Immunoglobulins · CPC title
Immunology or allergic disorders · CPC title
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