Hydrogel composition, manufacturing method thereof and hydrogel material
US-2024182651-A1 · Jun 6, 2024 · US
Method of crosslinking glycosaminoglycans
US11214655B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11214655-B2 |
| Application number | US-201716322615-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 2, 2017 |
| Priority date | Aug 3, 2016 |
| Publication date | Jan 4, 2022 |
| Grant date | Jan 4, 2022 |
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- Title
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Abstract
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A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.
First claim
Opening claim text (preview).
The invention claimed is: 1. Crosslinked glycosaminoglycans, wherein said glycosaminoglycans are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan, said glycosaminoglycans having a structure of Formula (I) wherein the boronate hemiester is selected from: wherein the boronate hemiester is grafted to said second glycosaminoglycan by the —NH 2 group of the boronate hemiester and forms an amide with a backbone carboxylate group of said second glycosaminoglycan, each GAG is hyaluronic acid and, diol functional moiety is selected from maltose, fructose, lactose and sorbitol. 2. Crosslinked glycosaminoglycans according to claim 1 , said crosslinked glycosaminoglycans having a structure of Formula (II) 3. A method of crosslinking a first glycosaminoglycan grafted with a diol-functional moiety having a diol portion and a second glycosaminoglycan grafted with a boronate hemiester, comprising crosslinking said first glycosaminoglycan with said second glycosaminoglycan by forming an alkoxyboronate ester anion linkage between the boronate hemiester of said second glycosaminoglycan and the diol portion of said diol-functional moiety of said first glycosaminoglycan, whereby the crosslinked glycosaminoglycans according to claim 1 are obtained. 4. Polymer composition comprising crosslinked glycosaminoglycans according to claim 1 and an aqueous buffer.
Assignees
Inventors
Classifications
Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title
- C08B37/0072Primary
Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates · CPC title
in aqueous media · CPC title
Crosslinking, e.g. vulcanising, of macromolecules (mechanical aspects B29C35/00; crosslinking agents C08K) · CPC title
Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title
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- What does patent US11214655B2 cover?
- A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan …
- Who is the assignee on this patent?
- Galderma Res & Dev, Centre Nat Rech Scient, Centre National De La Rech Scientfique
- What technology area does this patent fall under?
- Primary CPC classification C08B37/0072. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 04 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).