Automated vault module

Patent metadata

Field	Value
Publication number	US-11209344-B2
Application number	US-201615743222-A
Country	US
Kind code	B2
Filing date	Jul 12, 2016
Priority date	Jul 20, 2015
Publication date	Dec 28, 2021
Grant date	Dec 28, 2021

Abstract

A cryogenic storage system provides automated storage and retrieval of samples in a cryogenic environment, as well as automated transfer of individual samples between cryogenic environments. Stored samples are maintained under a cryogenic temperature threshold, while also enabling access to the samples. The samples are organized and tracked by scanning a barcode of each sample. Embodiments may also comprise multiple storage vaults and provide for transfer of individual samples between the storage vaults, as well as between a storage vault and a removable cryogenic storage device.

First claim

What is claimed is:

1. A cryogenic storage system comprising:
at least one vault configured to store a plurality of samples in at least a first cryogenic environment; and
a sample handling module including a robotic arm configured to transfer automatically an individual sample of the plurality of samples, independent of a remainder of the plurality of samples, between the first cryogenic environment and a second cryogenic environment
wherein, during the transfer between the first cryogenic environment and the second cryogenic environment, the sample handling module is further configured to 1) move the individual sample through a non-cryogenic environment, and 2) maintain the individual sample below a glass transition temperature of the individual sample during the transfer through the non-cryogenic environment.

2. The system of claim 1 , wherein the at least one vault includes a first vault encompassing the first cryogenic environment and a second vault encompassing the second cryogenic environment.

3. The system of claim 1 , further comprising a port configured to connect to a removable storage unit, the removable storage unit encompassing the second cryogenic environment.

4. The system of claim 1 , wherein the non-cryogenic environment is a dehumidified environment.

5. The system of claim 1 , wherein the sample handling module encompasses the non-cryogenic environment.

6. The system of claim 1 , wherein the at least one vault includes a liquid nitrogen refrigeration coil and an input flow of liquid nitrogen flowing into the refrigeration coil, wherein the input flow of liquid nitrogen transitions to a nitrogen gas in the refrigeration coil.

7. The system of claim 6 , wherein the refrigeration coil further includes an orifice into the at least one vault, the refrigeration coil adapted to at least partially exhaust the nitrogen gas into the at least one vault, the exhausted nitrogen maintaining a positive pressure in the at least one vault.

8. The system of claim 7 , wherein the refrigeration coil further includes an exhaust valve, the exhaust valve providing an exhaust flow of nitrogen gas into the sample handling module.

9. The system of claim 1 , wherein the plurality of samples are stored among a plurality of trays within the at least one vault.

10. The system of claim 9 , wherein the at least one vault is configured to transport an individual tray of the plurality of trays to a threshold of the at least one vault, the individual tray storing the individual sample.

11. The system of claim 10 , wherein the at least one vault is further configured to maintain the individual tray at a vertical level below that of a refrigeration coil of the at least one vault.

12. The system of claim 10 , wherein the at least one vault positions the individual tray to contact the threshold during the transport.

13. The system of claim 10 , wherein the sample handling module removes the individual sample from the individual tray during the transport.

14. The system of claim 1 , further comprising a sensor configured to identify the individual sample from among the plurality of samples.

15. The system of claim 14 , wherein the sensor includes a camera operable in the first cryogenic environment.

16. The system of claim 14 , wherein the sensor is configured to read a barcode of the individual sample prior to the transfer.

17. A method of cryogenic storage comprising:
storing a plurality of samples in at least one vault encompassing at least a first cryogenic environment;
operating a robotic arm to automatically transfer an individual sample of the plurality of samples, independent of a remainder of the plurality of samples, between the first cryogenic environment and a second cryogenic environment;
maintaining the individual sample below a glass transition temperature of the individual sample during the transfer; and
moving the individual sample through a non-cryogenic environment during the transfer.

18. The method of claim 17 , wherein the at least one vault includes a first vault encompassing the first cryogenic environment and a second vault encompassing the second cryogenic environment.

19. The method of claim 17 , wherein the second cryogenic environment is encompassed by a removable storage unit.

Assignees

• Brooks Automation Inc

Inventors

• Croquette Etienne
• Salvetti Matteo
• Affleck Rhett

Classifications

• G01N35/04 Primary

  Details of the conveyor system {(G01N35/021 - G01N35/028 take precedence)} · CPC title

• A01N1/145

  Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths · CPC title

• B01L7/50

  Cryostats · CPC title

• G01N35/02

  using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations {(G01N35/0098 and G01N35/0099 take precedence)} · CPC title

• F25D25/04

  by conveyors (in general B65G) · CPC title